Fig. 3
From: Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease
Fatty Acid Synthase Reactions. Fatty acid synthase (FASN) is a multi-complexed enzyme is responsible for the building of new fatty acids. The FASN enzymes are shown. The process begins with the condensation of malonyl-CoA onto an acyl-carrier protein group, followed by the extension of the malonyl-ACP with an acetyl-CoA subgroup. A series of reduction and dehydration steps result in the production of palmitic acid, a 16-carbon long saturated fatty acid