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Fig. 2 | Lipids in Health and Disease

Fig. 2

From: Reconstituted high-density lipoproteins promote wound repair and blood flow recovery in response to ischemia in aged mice

Fig. 2

The effect of rHDL on wound neovascularization, wound macrophage content and collagen deposition. Two full thickness wounds were created on the back flanks of 24-month-old C57Bl/6 J mice (n = 9/group). Mice received daily topical applications of rHDL (50 μg/wound) or PBS (vehicle). On Day 10 post-wounding, wound tissue was collected and sectioned for: a Capillaries using immunohistochemistry for CD31+ (brown, denoted by arrows); b Macrophage infiltration was identified in wound sections using immunohistochemistry for Mac-3+ (brown, denoted by arrows); c Collagen deposition was determined using Milligan’s trichrome stain (blue). Photomicrographs represent wounds stained for CD31+, Mac-3+ and collagen of PBS and rHDL wounds following sacrifice. Data is represented as mean ± SEM

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