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Fig. 3 | Lipids in Health and Disease

Fig. 3

From: Reconstituted high-density lipoproteins promote wound repair and blood flow recovery in response to ischemia in aged mice

Fig. 3

rHDL had no effect on gene expression of angiogenesis markers in wounds. Two full thickness wounds were created on the back flanks of 24-month-old C57Bl/6 J mice (n = 9/group). Mice received daily topical applications of rHDL (50 μg/wound) or PBS (vehicle). On Day 10 post-wounding, wound tissue was collected and RNA was isolated for qRT-PCR to assess gene expression or wound tissue was homogenized and used in ELISAs to assess protein. Measured markers include: a VEGF mRNA; b VEGF protein; c HIF-1α mRNA; d Siah1 mRNA; e Siah2 mRNA; f PHD2 mRNA; and g PHD3 mRNA. Data is represented as mean ± SEM

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