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Fig. 4 | Lipids in Health and Disease

Fig. 4

From: Reconstituted high-density lipoproteins promote wound repair and blood flow recovery in response to ischemia in aged mice

Fig. 4

rHDL promotes ischemia-induced blood perfusion in aged mice. Femoral artery ligation was performed on 24-month-old C57B1/6 J mice (n = 6–8) to induce ischemia in hindlimbs. Mice received intravenous injections of PBS or rHDL (40 mg/kg) on alternate days following ligation until sacrifice 21 days later. Images represent high (red) or low (blue) blood flow in animals treated with PBS or rHDL at Day 21. Laser Doppler Perfusion Index (LDPI) was determined as a ratio of ischemic (ISC) to non-ischemic (NON ISC) hindlimbs. Data is represented as mean ± SEM. Statistical analysis was performed by unpaired two-tailed t-test. *p < 0.05 vs. PBS control

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Lipids in Health and Disease

ISSN: 1476-511X