Table 1 Maximal viability concentration, IC10, and IC50 of fenofibrate, bezafibrate, and gemfibrozil in tested cell lines
From: Stimulating effect of normal-dosing of fibrates on cell proliferation: word of warning
PPARα ligand | max. viability | IC10 (μM) | IC50 (μM) | ||
|---|---|---|---|---|---|
concentration (μM) | relative viability (% of control) | ||||
HEK293 | fenofibtrate | 1.2 ± 0.8 | 147.0 ± 19.9 | 2.5 ± 0.4 | 12.0 ± 1.8 |
bezafibrate | 22.5 ± 5.0 | 129.0 ± 5.1 | 92.2 ± 25.2 | 175.3 ± 12.6 | |
gemfibrozil | 27.5 ± 9.6 | 137.0 ± 25.6 | 93.1 ± 30.9 | 180.4 ± 18.9 | |
WY-14643 | 10.0 ± 0.0 | 139.0 ± 8.2 | 82.4 ± 20.2 | 141.0 ± 3.8 | |
HepG2 | fenofibtrate | 20.0 ± 0.0 | 117.0 ± 7.0 | 76.1 ± 4.7 | 188.0 ± 8.5 |
bezafibrate | 23.3 ± 23.1 | 139.0 ± 42.6 | 200.0 ± 8.8 | 332.3 ± 16.1 | |
gemfibrozil | 10.0 ± 0.0 | 127.0 ± 10.4 | 251.3 ± 25.7 | 350.0 ± 13.3 | |
WY-14643 | 76.7 ± 5.8 | 173.0 ± 20.0 | 121.9 ± 26.2 | 265.1 ± 20.1 | |
HT-29 | fenofibtrate | 13.3 ± 5.8 | 137.0 ± 10.3 | 205.7 ± 4.0 | 327.0 ± 38.0 |
bezafibrate | 10.0 ± 0.0 | 141.0 ± 14.4 | 201.1 ± 27.7 | 268.8 ± 27.1 | |
gemfibrozil | 76.7 ± 5.8 | 145.0 ± 14.4 | 191.6 ± 37.6 | 261.2 ± 36.8 | |
WY-14643 | 63.3 ± 11.5 | 147.0 ± 21.3 | 184.0 ± 20.8 | 263.5 ± 15.3 | |