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Table 6 Fatty acid composition (% by weight) in red blood cell membranes

From: The role of background diet on the effects of eicosapentaenoic acid and docosahexaenoic acid supplementation in healthy pre-menopausal women: a randomized, cross-over, controlled study

  Baseline (mean ± SE) Low-fat diet (mean ± SE) p1 Habitual diet (mean ± SE) p2
(n = 41) (n = 41) (n = 8)
C14:0 0.38 ± 0.07 0.36 ± 0.07 0.84 0.40 ± 0.04 0.81
C14:1 0.23 ± 0.18 0.39 ± 0.07 <0.01 0.45 ± 0.14 0.35
C15:0 0.22 ± 0.04 0.20 ± 003 0.69 0.19 ± 0.03 0.56
C16:0 23.59 ± 1.31 23.71 ± 1.44 0.95 22.6 ± 1.31 0.60
C16:1 0.22 ± 0.07 0.30 ± 0.10 <0.01 0.32 ± 0.04 0.24
C18:0 12.15 ± 0.81 12.04 ± 0.85 0.92 14.07 ± 0.51 <0.05
C18:1 17.04 ± 1.07 17.44 ± 1.25 <0.05 18.68 ± 0.43 0.18
C18:2n-6 12.20 ± 1.53 10.56 ± 2.13 <0.01 10.56 ± 0.86 0.36
C18:3n-6 0.04 ± 0.04 0.04 ± 0.03 1.0 0.03 ± 0.02 1.0
C18:3n-3 0.19 ± 0.06 0.18 ± 0.06 0.91 0.22 ± 0.06 0.73
C18:4n-3 0.02 ± 0.02 0.02 ± 0.02 1.0 0.10 ± 0.02 <0.05
C20:0 0.20 ± 0.15 0.16 ± 0.07 0.81 0.05 ± 0.02 <0.05
C20:1 0.31 ± 0.14 0.23 ± 0.07 <0.01 0.23 ± 0.04 0.59
C20:2n-6 0.13 ± 0.12 0.02 ± 0.02 <0.01 0.21 ± 0.06 <0.05
C20:3n-6 1.43 ± 0.34 1.25 ± 0.27 <0.01 1.34 ± 0.23 0.83
C20:4n-6 (AA) 12.96 ± 1.28 11.98 ± 1.55 <0.01 12.16 ± 1.21 0.66
C20:3n-3 0.01 ± 0.02 0.01 ± 0.01 1.0 0.01 ± 0.01 1.0
C20:4n-3 0.05 ± 0.04 0.05 ± 0.03 1.0 0.05 ± 0.05 1.0
C20:5n-3 (EPA) 0.80 ± 0.35 2.64 ± 0.62 <0.01 2.27 ± 0.4 P < 0.05
C22:0 1.15 ± 0.31 0.76 ± 0.19 <0.05 0.00 ± 0.00 <0.01
C22:1 0.99 ± 1.00 0.44 ± 0.16 <0.01 0.43 ± 0.33 0.60
C22:2n-6 0.10 ± 0.07 0.10 ± 0.04 1.0 0.00 ± 0.00 <0.01
C22:4n-6 3.08 ± 0.59 2.39 ± 0.53 <0.01 2.11 ± 0.44 0.21
C22:5n-6 0.33 ± 0.26 0.38 ± 0.66 0.94 0.02 ± 0.03 0.26
C22:5n-3 2.25 ± 0.44 3.74 ± 0.72 <0.01 3.70 ± 0.46 0.07
C22:6n-3 (DHA) 4.37 ± 1.09 6.91 ± 1.03 <0.01 6.08 ± 1.04 <0.05
C24:0 1.74 ± 1.30 1.89 ± 1.33 0.94 1.47 ± 0.16 <0.01
C24:1 3.78 ± 2.42 1.93 ± 0.45 <0.01 2.59 ± 0.46 <0.05
Saturated 39.44 ± 2.30 39.12 ± 1.71 0.91 38.75 ± 1.81 0.82
MUFA 22.58 ± 3.13 20.73 ± 1.48 0.59 21.04 ± 1.41 <0.05
PUFA 37.97 ± 2.71 40.13 ± 2.61 <0.01 39.94 ± 2.95 0.63
n-3 7.63 ± 1.61 13.57 ± 1.96 <0.01 12.03 ± 1.62 <0.05
n-6 30.20 ± 2.38 26.40 ± 2.14 <0.01 26.41 ± 1.90 0.23
n-3:n-6 0.25 ± 0.02 0.51 ± 0.02 <0.01 0.46 ± 0.007 <0.05
AA/EPA 19.01 ± 7.77 4.86 ± 1.74 <0.01 5.30 ± 1.04 0.10
  1. Data are expressed as a percentage of total fatty acids ± standard error. p1, significance of paired t-test of baseline vs. after low-fat diet, p2, significance of paired t-test of after low-fat diet vs. after habitual diet