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Table 4 The genotoxic effects of MAS at different concentration in A549 and HepG2 cells using the comet assay (Mean ± SEM, n = 2)

From: Antibacterial, cytotoxic and genotoxic activity of nitrogenated and haloid derivatives of C50–C60 and C70–C120 polyprenol homologs

Compound, concentration (μg/mL) % DNA tail Tail moment (arbitrary units)
A549 HepG2 A549 HepG2
MAS
 10 31.03 ± 3.31* 35.58 ± 2.84* 34.73 ± 3.02* 36.78 ± 2.98*
 20 57.99 ± 4.02* 59.92 ± 4.14* 54.87 ± 4.77* 57.45 ± 4.63*
 40 69.49 ± 4.89* 73.95 ± 5.23* 69.06 ± 5.11* 74.21 ± 3.96*
 Control 9.15 ± 1.21 9.49 ± 1.10 4.95 ± 0.95 5.12 ± 0.87
 EP (0.5 μg/mL) 70.08 ± 4.33* 77.12 ± 4.01* 75.54 ± 3.86* 80.63 ± 4.55*
  1. aMean ± standard error from 2 independent experiments; 100 cells were counted for each experiment
  2. *P < 0.01 versus control using Student’s t-test