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Table 4 The genotoxic effects of MAS at different concentration in A549 and HepG2 cells using the comet assay (Mean ± SEM, n = 2)

From: Antibacterial, cytotoxic and genotoxic activity of nitrogenated and haloid derivatives of C50–C60 and C70–C120 polyprenol homologs

Compound, concentration (μg/mL)

% DNA tail

Tail moment (arbitrary units)

A549

HepG2

A549

HepG2

MAS

 10

31.03 ± 3.31*

35.58 ± 2.84*

34.73 ± 3.02*

36.78 ± 2.98*

 20

57.99 ± 4.02*

59.92 ± 4.14*

54.87 ± 4.77*

57.45 ± 4.63*

 40

69.49 ± 4.89*

73.95 ± 5.23*

69.06 ± 5.11*

74.21 ± 3.96*

 Control

9.15 ± 1.21

9.49 ± 1.10

4.95 ± 0.95

5.12 ± 0.87

 EP (0.5 μg/mL)

70.08 ± 4.33*

77.12 ± 4.01*

75.54 ± 3.86*

80.63 ± 4.55*

  1. aMean ± standard error from 2 independent experiments; 100 cells were counted for each experiment
  2. *P < 0.01 versus control using Student’s t-test
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Lipids in Health and Disease

ISSN: 1476-511X