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Table 2 Cytotoxic activity of the oil of P. aequale on cancer cell linesa

From: Composition and cytotoxic and antioxidant activities of the oil of Piper aequale Vahl

Sample   IC50 (μg/ml)a   Hemolysis
  HCT-116 (Colon) SKMEL19 (Melanoma) ACP-03 (Gastric) (μg/ml)
Oil 8.69 (7.20–10.50) > 25 1.54 (1.34–1.77) > 200
Doxorubicin 0.10 μM (0.05–0.28) 0.3 μM (0.24–0.38) 0.27 μM (0.22–0.33) > 200
  1. aData are presented as IC50 values and 95 % confidence intervals obtained by nonlinear regression for all cell lines from three independent experiments. Doxorubicin (DOX) was used as positive control. Only compounds with IC50 values lower than 25 μg/mL in at least one cell line were considered active