Association of KCTD10, MVK, and MMAB polymorphisms with dyslipidemia and coronary heart disease in Han Chinese population

Table 2 Summary results of associations between 17 potentially functional SNPs in three genes (KCTD10, MVK and MMAB) and risk of dyslipidemia

Gene	SNP	Allele^a	Cases^b	Controls^b	MAF	HWE^c	Codominant model^d		Additive model^d
Gene	SNP	Allele^a	(N = 399)	(N = 465)	(Cases/controls)	HWE^c	P _het	P _hom	P _add
KCTD10	rs1477117	G/A	279/115/1	326/123/10	0.148/0.156	0.686	0.349	0.025	0.791
	rs11066782	C/T	283/113/1	311/135/11	0.145/0.172	0.414	0.929	0.014	0.174
	rs11613718	C/T	272/120/1	308/139/9	0.155/0.172	0.138	0.762	0.038	0.521
	rs11615336	C/A	282/101/1	317/120/10	0.134/0.157	0.730	0.931	0.024	0.288
	rs7295954	C/T	322/60/1	381/69/0	0.081/0.077	0.078	0.399	–	0.323
	rs1045582	G/T	284/104/2	321/124/6	0.138/0.151	0.118	0.888	0.112	0.459
MVK	rs3759387	G/T	297/97/3	330/126/7	0.130/0.151	0.194	0.990	0.303	0.687
MVK	rs2287218	C/T	279/112/4	324/122/10	0.152/0.156	0.707	0.494	0.095	0.878
MMAB	rs12817689	A/G	284/105/3	319/113/10	0.142/0.150	0.998	0.614	0.047	0.635
	rs2241201	C/G	238/138/11	288/148/21	0.207/0.208	0.722	0.358	0.268	0.928
	rs877710	C/G	194/177/26	219/201/40	0.288/0.305	0.522	0.656	0.330	0.714
	rs11067233	C/G	315/74/2	329/118/8	0.100/0.147	0.486	0.072	0.145	0.026
	rs9593	A/T	187/162/26	212/196/39	0.285/0.306	0.506	0.958	0.333	0.539
	rs11067227	C/T	316/67/2	333/104/7	0.092/0.133	0.729	0.116	0.295	0.065
	rs7134594	C/T	187/178/26	213/196/40	0.294/0.307	0.286	0.786	0.364	0.665
	rs11831226	A/C	320/58/2	391/71/0	0.082/0.077	0.074	0.491	–	0.342
	rs8228	A/G	322/63/0	380/69/0	0.082/0.077	0.078	0.349	–	0.349

MAF minor allele frequency
^aMajor/minor allele
^bMajor homozygote/heterozygote/rare homozygote
^cHardy-Weinberg equilibrium test among controls
^dLogistic regression with adjustment for sex, age, smoking and BMI were used to test associations in codominant (P _het: heterozygote vs. major homozygote; P _hom: minor homozygote vs. major homozygote) and additive (P _add: minor homozygote vs. heterozygote vs. major homozygote) models

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