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Table 2 Correlations between Lp-PLA2, sPLA2 and clinical parameters in newly diagnosed type 2 diabetes

From: Effect of intensive insulin treatment on plasma levels of lipoprotein-associated phospholipase A2 and secretory phospholipase A2 in patients with newly diagnosed type 2 diabetes

 

Lp-PLA2 (ng/ml)

sPLA2 (ng/ml)

Body mass index (kg/m2)

r = 0.121, P = 0.311

r = 0.123, P = 0.311

Waist circumference (cm)

r = 0.023, P = 0.846

r = 0.243, P = 0.043*

Systolic pressure (mmHg)

r = 0.080, P = 0.460

r = 0.046, P = 0.677

Diastolic pressure (mmHg)

r = 0.077, P = 0.472

r = 0.079, P = 0.467

HbA1c (%)

r = 0.283, P = 0.020*

r = 0.076, P = 0.545

Total cholesterol (mmol/L)

r = 0.224, P = 0.070

r = 0.147, P = 0.247

Triglyceride (mmol/L)

r = 0.106, P = 0.448

r = 0.078, P = 0.584

HDL-C (mmol/L)

r = 0.240, P = 0.072

r = 0.176, P = 0.199

LDL-C (mmol/L)

r = 0.269, P = 0.029*

r = 0.177, P = 0.162

HOMA-IR

r = 0.309, P = 0.037*

r = 0.506, P < 0.01**

HOMA-β

r = −0.116, P = 0.353

r = −0.050, P = 0.670

IVGTT AUCIns

r = −0.012, P = 0.294

r = −0.038, P = 0.742

IVGTT AUCPG

r = 0.120, P = 0.338

r = 0.028, P = 0.809

AIR3–5

r = −0.029, P = 0.815

r = −0.006, P = 0.961

â–³Ins30/â–³G30

r = −0.023, P = 0.855

r = −0.055, P = 0.633

OGTT AUCIns

r = −0.088, P = 0.483

r = −0.055, P = 0.635

OGTT AUCPG

r = 0.049, P = 0.688

r = 0.042, P = 0.709

MBCI

r = −0.099, P = 0.427

r = −0.206, P = 0.073

White blood cells (×109/L)

r = 0.137, P = 0.262

r = 0.029, P = 0.796

Free fatty acid (umol/L)

r = 0.167, P = 0.184

r = 0.096, P = 0.408

hsCRP (mg/L)

r = 0.023, P = 0.852

r = 0.149, P = 0.189

  1. Abbreviations: HbA1c hemoglobin A1c, IVGTT AUC Glu the areas under the curve of glucose in intravenous glucose tolerance test, OGTT AUC Glu the areas under the curve of glucose in oral glucose tolerance test, HDL-C high density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol, hsCRP high sensitivity C reactive protein; HOMA-IR, IAI, QUICKI and ISI ced are indicators of insulin sensitivity (HOMA-IR = FPG × FIns/22.5; IAI = 1/(FIns × FPG); QUICKI = 1/(lgFPG + lgFIns); ISIced = MCR/LgMSI, MCR = M/MG, MG = (FPG + Glu30 min + Glu60 min + Glu120 min)/4, MSI = (FIns + Ins30 min + Ins60 min + Ins120 min)/4, M = 75000/120 + (FPG - Glu120 min) × 1.15 × 180 × 0.19 × body weight/120), HOMA-β, AIR 3–5 ∆Ins30/∆G30, MBCI, IVGTT AUCIns and OGTT AUCIns are indicators of island function (HOMA-β = 20 × FIns/(FPG - 3.5); AIR3–5 is calculated as the average increase of plasma insulin between the 3rd or 5th minute and the base line in IVGTT; ∆Ins30/∆G30 = (Ins30min - FIns)/(Glu30min - FPG); MBCI = (FPG × FIns)/(Glu120min + Glu60min - 7); AUCIns, the area under the curve (AUC) of insulin, IVGTT AUCIns = (3 × FINS+ 5 × INS3+ 4 × INS5+ 5 × INS7+ 3 × INS10)/2, OGTT AUCIns = (FINS + 2 × INS30+ 3 × INS60+ 4 × INS120+ 2 × INS180)/4; all the indicators regarding to β cell function were respectively divided by HOMA-IR to guarantee from interference of insulin resistance), Lp-PLA 2 lipoprotein-associated phospholipase A2, sPLA 2 secretory phospholipase A2
  2. Values of P < 0.05 are statistically significant
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Lipids in Health and Disease

ISSN: 1476-511X