From: Impact of dipeptidyl peptidase-4 inhibitors on serum adiponectin: a meta-analysis
Studies | Patients (N) | Treatment | Diabetes duration (months) | Adiponectin (μg/mL) | HbA1c (%) | Treatment duration (months) | Patient characteristics | |||
---|---|---|---|---|---|---|---|---|---|---|
BMI (kg/m2) | Age (years) | Male (N) | Weight (kg) | |||||||
Derosa, 2012 [22] | 91 | sitagliptin + metformin | 5.8 | 5.0 | 8.1 | 12 | 28.1 | 55.9 | 42 | 78.4 |
 | 87 | placebo + metformin | 5.4 | 5.2 | 8.0 |  | 28.9 | 54.8 | 44 | 78.6 |
Derosa, 2010 [23] | 75 | sitaliptin + pioglitazone | 60 | 5.4 | 8.5 | 12 | 27.9 | 57 | 37 | 78.7 |
 | 76 | metformin + pioglitazone | 72 | 5.3 | 8.4 |  | 27.7 | 58 | 39 | 77.3 |
Forst, 2013 [45] | 22 | vildagliptin + metformin | 100.8 | 5.0 | 7.41 | 6 | Not available | Not available | Not available | 99.3 |
 | 22 | glimepiride + metformin | 73.2 | 5.6 | 7.28 |  | Not available | Not available | Not available | 93.7 |
Mikada, 2014 [47] | 14 | sitagliptin | 91.2 | 6.5 | 7.45 | 6 | 28.8 | 59.2 | 11 | 76.8 |
 | 14 | miglitol | 111.6 | 7.4 | 6.90 |  | 29.5 | 58.7 | 11 | 81.4 |
Hibuse, 2014 [48] | 16 | sitagliptin | 57.6 | 6.7 | 7.5 | 3 | 24.9 | 63 | 9 | Not available |
 | 10 | sulfonylurea and/or biguanide | 45.6 | 4.6 | 7.8 |  | 28.1 | 56 | 6 | Not available |
Takeshita, 2015 [49] | 30 | sitagliptin | 86.4 | 4.5 | 6.7 | 4 | 24.5 | 61.0 | 18 | 62.5 |
 | 30 | mitiglinide | 145.2 | 5.0 | 6.9 |  | 24.2 | 65.8 | 19 | 63.2 |
Derosa, 2012 [50] | 84 | vildagliptin + metformin | 6.1 | 5.2 | 8.1 | 12 | 27.9 | 54.2 | 42 | 76.9 |
 | 83 | placebo + metformin | 6.3 | 5.4 | 8.2 |  | 27.8 | 52.4 | 43 | 78.5 |
Derosa, 2014 [51] | 86 | vildagliptin | 6.9 | 4.8 | 7.9 | 6 | 27.9 | 59.8 | 42 | 77.8 |
 | 81 | glimepiride | 6.7 | 4.5 | 7.8 |  | 27.7 | 56.8 | 36 | 77.2 |
Takeshita, 2015 [52] | 58 | vildagliptin | Not available | 3.6  | 8.1 | 3 | 24.5 | Not available | 36 | 63.2 |
 | 54 | liraglutide | Not available | 3.8 | 8.0 |  | 25.4 | Not available | 35 | 65.8 |
Shimoda, 2014 [53] | 25 | sitagliptin | Not available | 7.0 | 7.3 | 3 | 24.9 | 63.9 | 16 | Not available |
 | 25 | glimepiride | Not available | 7.6 | 7.5 |  | 25.3 | 62.4 | 15 | Not available |