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Table 4 Univariate and multivariate analysis for risk factors to predict MACE and cardiac death

From: Impact of low high-density lipoprotein-cholesterol level on 2-year clinical outcomes after acute myocardial infarction in patients with diabetes mellitus

 

MACE

Cardiac death

Risk Factor

β

HR (95% CI)

p-value

β

HR (95% CI)

p-value

Univariate analysis

 Age

0.04

1.04 (1.007 – 1.066)

0.014

0.10

1.10 (1.048 – 1.158)

<0.001

 Male

−0.10

0.90 (0.513 – 1.588)

0.723

−0.33

0.72 (0.306 – 1.677)

0.443

 BMI

−0.02

0.98 (0.895 – 1.073)

0.666

−0.20

0.82 (0.703 – 0.947)

0.008

 Current Smoking

−0.41

0.66 (0.354 – 1.243)

0.200

−0.56

0.57 (0.210 – 1.543)

0.268

 Previous MI

−0.55

0.58 (0.327 – 1.026)

0.061

−0.92

0.40 (0.157 – 1.023)

0.056

 Hypertension

1.67

5.31 (2.113 – 13.363)

<0.001

1.26

3.51 (1.038 – 11.858)

0.043

 HDL-C

−0.05

0.95 (0.928 – 0.981)

0.001

−0.08

0.92 (0.879 – 0.963)

<0.001

 LDL-C

−0.01

0.99 (0.986 – 1.001)

0.098

−0.01

1.00 (0.983 – 1.007)

0.395

 eGFR

−0.02

0.99 (0.977 – 0.994)

0.001

−0.03

0.973 (0.960 – 0.986)

<0.001

 Hba1c

0.02

1.02 (0.852 – 1.231)

0.802

0.13

1.14 (0.880 – 1.482)

0.319

 hsCRP

0.002

1.00 (0.988 – 1.017)

0.786

0.003

1.00 (0.985 – 1.022)

0.739

 STEMI at admission

−0.55

0.58 (0.327 – 1.026)

0.061

−0.92

0.40 (0.157 – 1.023)

0.056

 Primary PCI

−0.38

0.685 (0.397 – 1.183)

0.175

−1.27

0.28 (0.115 – 0.693)

0.006

 MVD

0.13

1.14 (0.649 – 2.008)

0.647

−0.22

0.80 (0.347 – 1.859)

0.608

 Lesion type (B2/C)

0.05

1.05 (0.466 – 2.346)

0.914

−0.60

0.55 (0.175 – 1.727)

0.306

 Stent diameter ≤2.75 mm

0.02

1.02 (0.490 – 2.124)

0.958

−1.27

0.28 (0.035 - 2.211)

0.227

 Stent length ≥28 mm

0.49

1.64 (0.842 – 3.174)

0.146

0.41

1.51 (0.437 – 5.209)

0.516

 LVEF

−0.04

0.96 (0.941 – 0.986)

0.002

−0.10

0.904 (0.870 – 0.939)

<0.001

 Statin at discharge

−0.35

0.71 (0.354 – 1.407)

0.322

−0.83

0.44 (0.170 – 1.113)

0.083

Multivariate analysis

 HDL-C

−0.05

0.95 (0.905 - 0.999)

0.047

-

-

-

 Age

−0.05

0.96 (0.906 – 1.006)

0.085

-

-

-

 BMI

−0.17

0.84 (0.714 – 0.993)

0.041

−0.31

0.73 (0.537 – 1.002)

0.051

 Hypertension

1.57

4.80 (1.052 – 21.927)

0.043

-

-

-

 eGFR

−0.02

0.981 (0.966 – 0.996)

0.016

−0.02

0.98 (0.954-1.004)

0.093

 Stent diameter ≤2.75 mm

-

-

-

−1.81

0.16 (0.017 – 1.587)

0.119

 LVEF

-

-

-

−0.11

0.893 (0.828 – 0.964)

0.004

  1. MACE major adverse cardiovascular events, HR hazard ratio, 95% CI 95% confidence interval, BMI body mass index, MI myocardial infarction, LDL-C low-density lipoprotein cholesterol, eGFR estimated glomerular filtration rate, hsCRP high-sensitivity C-reactive protein, STEMI ST-segment elevation myocardial infarction, PCI percutaneous coronary intervention, MVD multi-vessel disease, LVEF left ventricular ejection fraction, n.d. not determined
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Lipids in Health and Disease

ISSN: 1476-511X