Phenotype | SHR | SHR-Dca+/− | SHR-Dca−/− | p-value |
---|---|---|---|---|
Plasma SOD | 0.343 ± 0.030 | 0.319 ± 0.030 | 0.283 ± 0.034 | 0.43 |
Liver SOD | 0.097 ± 0.006 | 0.074 ± 0.005† | 0.082 ± 0.003* | 0.012 |
Kidney SOD | 0.070 ± 0.002 | 0.040 ± 0.002‡,b | 0.059 ± 0.008 | 0.0010 |
Heart SOD | 0.085 ± 0.008 | 0.079 ± 0.009 | 0.083 ± 0.009 | 0.88 |
Plasma CAT | 341 ± 16 | 354 ± 30 | 414 ± 55 | 0.36 |
Liver CAT | 773 ± 37 | 1081 ± 24‡,c | 827 ± 31 | 0.000004 |
Kidney CAT | 464 ± 19 | 571 ± 41 | 539 ± 46 | 0.16 |
Heart CAT | 629 ± 36 | 679 ± 31 | 621 ± 38 | 0.44 |
Plasma GSH-Px | 546 ± 30 | 379 ± 27† | 426 ± 60 | 0.027 |
Liver GSH-Px | 417 ± 27 | 320 ± 18* | 389 ± 33 | 0.042 |
Kidney GSH-Px | 506 ± 31 | 378 ± 23†,a | 460 ± 24 | 0.0092 |
Heart GSH-Px | 624 ± 35 | 577 ± 20 | 612 ± 16 | 0.38 |
Plasma GR | 212 ± 21 | 158 ± 13*,c | 259 ± 13 | 0.001 |
Liver GR | 387 ± 22 | 430 ± 14 | 372 ± 32 | 0.20 |
Kidney GR | 273 ± 16 | 241 ± 9 | 198 ± 31 | 0.06 |
Heart GR | 244 ± 24 | 228 ± 16 | 192 ± 26 | 0.27 |
Plasma GSH | 31.0 ± 2.0 | 22.3 ± 1.1‡ | 21.9 ± 1.0‡ | 0.0004 |
Liver GSH | 24.6 ± 1.5 | 23.4 ± 1.3 | 28.2 ± 1.8 | 0.10 |
Kidney GSH | 25.1 ± 1.7 | 19.8 ± 1.2 | 24.6 ± 1.9 | 0.06 |
Heart GSH | 25.8 ± 2.4 | 27.4 ± 2.0 | 25.5 ± 1.2 | 0.75 |
Plasma TBARS | 1.72 ± 0.05 | 2.32 ± 0.13† | 2.24 ± 0.13† | 0.0030 |
Liver TBARS | 0.62 ± 0.04 | 1.05 ± 0.09‡ | 0.87 ± 0.05* | 0.0016 |
Kidney TBARS | 1.27 ± 0.11 | 1.49 ± 0.14 | 1.54 ± 0.16 | 0.37 |
Heart TBARS | 1.88 ± 0.11 | 2.38 ± 0.23 | 1.97 ± 0.23 | 0.20 |
Plasma CD | 31.6 ± 2.7 | 34.8 ± 1.5 | 33.0 ± 2.0 | 0.54 |
Liver CD | 33.7 ± 1.0 | 32.1 ± 1.6 | 29.1 ± 2.2 | 0.18 |
Kidney CD | 19.8 ± 2.3 | 20.7 ± 1.6 | 20.8 ± 2.3 | 0.93 |
Heart CD | 15.1 ± 1.1 | 19.5 ± 1.4 | 19.1 ± 1.9 | 0.11 |