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Table 1 Leukocyte free radical generation, plasma lipid peroxides and phospholipid content of unsaturated fatty acids in patients with sepsis

From: Combination of aspirin with essential fatty acids is superior to aspirin alone to prevent or ameliorate sepsis or ARDS

Measurement

Control (n = 10)

Sepsis (n =14)

μM of formazan (O2 −1)

without PMA

4.5 ± 1.0

6.48 ± 3.0*

with PMA

40.3 ± 9.7

62.2 ± 18*

μM of H2O2

without PMA

4.76 ± 0.56

9.0 ± 4.3*

With PMA

44.2 ± 6.16

70.3 ± 50

nmoles of MDA-eq

1.56 ± 0.36

2.37 ± 0.6*

18:3 n-6 (GLA)

0.13 ± 0.09

0.04 ± 0.05*

20:3 n-6 (DGLA)

3.2 ± 0.79

0.46 ± 0.54*

20:4 n-6 (AA)

8.8 ± 2.0

5.8 ± 1.6*

18:3 n-3 (ALA)

0.27 ± 0.12

0.16 ± 0.11*

20:5 n-3 (EPA)

0.25 ± 0.26

0.01 ± 0.01*

22:6 n-3 (DHA)

1.43 ± 0.43

1.2 ± 1.14

  1. All values are expressed as mean ± SE. *P < 0.05 compared to control. All fatty acids are expressed as % of PL (phospholipid)