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Table 1 Leukocyte free radical generation, plasma lipid peroxides and phospholipid content of unsaturated fatty acids in patients with sepsis

From: Combination of aspirin with essential fatty acids is superior to aspirin alone to prevent or ameliorate sepsis or ARDS

Measurement Control (n = 10) Sepsis (n =14)
μM of formazan (O2 −1) without PMA 4.5 ± 1.0 6.48 ± 3.0*
with PMA 40.3 ± 9.7 62.2 ± 18*
μM of H2O2 without PMA 4.76 ± 0.56 9.0 ± 4.3*
With PMA 44.2 ± 6.16 70.3 ± 50
nmoles of MDA-eq 1.56 ± 0.36 2.37 ± 0.6*
18:3 n-6 (GLA) 0.13 ± 0.09 0.04 ± 0.05*
20:3 n-6 (DGLA) 3.2 ± 0.79 0.46 ± 0.54*
20:4 n-6 (AA) 8.8 ± 2.0 5.8 ± 1.6*
18:3 n-3 (ALA) 0.27 ± 0.12 0.16 ± 0.11*
20:5 n-3 (EPA) 0.25 ± 0.26 0.01 ± 0.01*
22:6 n-3 (DHA) 1.43 ± 0.43 1.2 ± 1.14
  1. All values are expressed as mean ± SE. *P < 0.05 compared to control. All fatty acids are expressed as % of PL (phospholipid)