Fig. 1
From: B cells interactions in lipid immune responses: implications in atherosclerotic disease
Participation of B cell receptors during atherosclerotic plaque formation. During atherosclerotic plaque formation we speculate that B cells have an important participation. The expression of LDLR contributes with the recognition of LDL molecules and its antigenic presentation trough CD1d to iNKTs exacerbates the disease. Persistence presence of LDL molecule favors its oxidation; oxLDLs are recognized by CD36 and SR-BI, leading to the development of lipid load cells either contributing to atherosclerosis (panel in red) or depending on the disease stage, diminishing the inflammatory process (panel in green). On the contrary, the up regulation of FcγRIIB receptors with inhibitory activity induce anti-inflammatory responses after recognition of immune complexes of IgG and oxLDL associated with an atheroprotector role (panel in green)