Table 1 Comparison of demographic, lifestyle characteristics, serum lipid profiles and the genotype and allele frequencies of the SPTLC3 rs364585 SNP between the Han and Jing populations
Parameter | Han | Jing | t (x 2) | P |
|---|---|---|---|---|
No. of patients | 824 | 783 | Â | Â |
Male/female | 405 / 419 | 389 / 394 | 0.045 | 0.832 |
Age (years) | 57.27 ± 12.40 | 57.19 ± 12.50 | 0.122 | 0.903 |
Height (cm) | 157.28 ± 8.27 | 158.08 ± 7.87 | −1.984 | 0.047 |
Weight (kg) | 56.35 ± 9.41 | 58.80 ± 10.09 | −5.018 | 0.000 |
Body mass index (kg/m 2) | 22.74 ± 3.19 | 23.46 ± 3.20 | −4.517 | 0.000 |
Waist circumference (cm) | 77.46 ± 8.90 | 80.38 ± 9.20 | −6.647 | 0.000 |
Smoking status (n%) | ||||
 0 g/day (non-smoker) | 666 (80.8) | 656 (83.8) |  |  |
  ≤ 20 cigarettes/day | 31 (3.8) | 34 (4.3) |  |  |
  > 20 cigarettes/day | 127 (15.4) | 93 (11.9) | 4.425 | 0.109 |
Alcohol consumption (n%) | ||||
 0 g/day (non-drinker) | 648 (78.6) | 681 (87.0) |  |  |
  ≤ 25 g/day | 40 (4.9) | 83 (10.6) |  |  |
  > 25 g/day | 136 (16.5) | 19 (2.4) | 103.189 | 0.000 |
Systolic blood pressure (mmHg) | 132.40 ± 18.90 | 132.18 ± 21.91 | 0.215 | 0.830 |
Diastolic blood pressure (mmHg) | 81.78 ± 10.45 | 80.34 ± 10.30 | 2.778 | 0.006 |
Pulse pressure (mmHg) | 50.62 ± 15.13 | 51.84 ± 17.81 | −1.481 | 0.139 |
Glucose (mmol/l) | 6.63 ± 1.06 | 6.86 ± 1.62 | −3.390 | 0.001 |
Total cholesterol (mmol/l) | 4.98 ± 0.85 | 5.08 ± 0.90 | −2.286 | 0.022 |
Triglyceride (mmol/l) | 1.39(0.67) | 1.43(0.75) | −0.349 | 0.727 |
HDL-C (mmol/l) | 1.80 ± 0.52 | 1.79 ± 0.46 | 0.419 | 0.676 |
LDL-C (mmol/l) | 2.87 ± 0.44 | 2.82 ± 0.43 | 2.593 | 0.010 |
Apo A1 (g/l) | 1.33 ± 0.20 | 1.28 ± 0.22 | 4.116 | 0.000 |
ApoB (g/l) | 1.05 ± 0.24 | 1.04 ± 0.23 | 1.023 | 0.307 |
ApoA1/ApoB | 1.32 ± 0.36 | 1.29 ± 0.38 | 1.481 | 0.139 |
Genotype [n(%)] | ||||
 GG | 223(27.1) | 235(30.0) |  |  |
 GA | 392(47.6) | 371(47.4) |  |  |
 AA | 209(25.4) | 177(22.6) | 2.501 | 0.286 |
Allele [n(%)] | ||||
 G | 838(50.9) | 841(53.7) |  |  |
 A | 810(49.1) | 725(46.3) | 2.622 | 0.105 |