Table 2 Comparison of demographic, lifestyle characteristics, serum lipid profiles and the genotype and allele frequencies of the SPTLC3 rs364585 SNP between males and females in the Han and Jing populations

No. of patients

405

419

389

394

Age (years)

56.88 ± 11.64

57.65 ± 13.10

−0.888

0.375

57.77 ± 14.20

56.64 ± 12.27

1.129

0.234

Height (cm)

162.99 ± 5.56

151.76 ± 6.51

26.538

0.000

162.94 ± 6.60

153.29 ± 5.82^c

21.728

0.000

Weight (kg)

60.29 ± 8.53

52.54 ± 8.83

12.820

0.000

62.35 ± 10.02^b

55.30 ± 8.87^c

10.437

0.000

Body mass index (kg/m²)

22.68 ± 2.81

22.80 ± 3.52

−0.560

0.567

23.42 ± 3.10^c

23.50 ± 3.30^b

−0.333

0.740

Waist circumference (cm)

78.31 ± 8.19

76.63 ± 9.49

2.730

0.006

81.59 ± 9.83^c

79.19 ± 8.40^c

3.677

0.000

 Non-smoker

248 (61.2)

418 (99.8)

264 (67.9)

392 (99.5)

 Smoker

157 (38.8)

1(0.2)

196.00

0.000

115 (32.1)^a

2 (0.5)

133.70

0.000

 Non- drinker

232 (57.3)

416 (99.3)

292(75.1)

389 (98.7)

 Drinker

173 (42.7)

3 (0.7)

216.01

0.000

97(24.9)^c

5 (1.3)

96.65

0.000

Systolic blood pressure (mmHg)

130.14 ± 16.58

134.58 ± 20.79

−3.392

0.001

132.26 ± 20.77

132.11 ± 23.00

0.096

0.924

Diastolic blood pressure (mmHg)

81.99 ± 10.38

81.58 ± 10.50

0.554

0.580

80.68 ± 10.61

80.02 ± 10.00^a

0.901

0.368

Pulse pressure (mmHg)

48.16 ± 13.21

53.00 ± 16.44

−4.651

0.000

51.59 ± 16.87^b

52.09 ± 18.71

−0.403

0.687

Glucose (mmol/l)

6.58 ± 1.08

6.68 ± 1.04

−1.348

0.178

6.94 ± 1.75^c

6.79 ± 1.49

1.307

0.191

Total cholesterol (mmol/l)

4.90 ± 0.83

5.06 ± 0.87

−2.734

0.006

5.04 ± 0.82^a

5.11 ± 0.97

−1.165

0.244

Triglyceride (mmol/l)

1.39(1.71)

1.40(1.63)

−2.720

0.007

1.48(1.83)

1.40(1.63)

−0.963

0.336

HDL-C (mmol/l)

1.74 ± 0.55

1.87 ± 0.48

−2.417

0.000

1.75 ± 0.46

1.83 ± 0.45

−2.417

0.016

LDL-C (mmol/l)

2.86 ± 0.43

2.89 ± 0.45

−3.615

0.382

2.82 ± 0.37

2.81 ± 0.48^a

0.183

0.855

Apo A1 (g/l)

1.33 ± 0.21

1.32 ± 0.20

0.263

0.793

1.26 ± 0.21^c

1.30 ± 0.23

−2.764

0.006

ApoB (g/l)

1.06 ± 0.23

1.05 ± 0.26

0.465

0.642

1.04 ± 0.22

1.03 ± 0.24

1.011

0.312

ApoA1/ApoB

1.31 ± 0.36

1.33 ± 0.37

−0.697

0.486

1.26 ± 0.40

1.32 ± 0.37

−2.102

0.036

 GG

105(25.9)

118(28.2)

108(27.8)

127(32.2)

 GA

188(46.4)

204(48.7)

188(48.3)

183(46.4)

 AA

112(27.7)

97(23.2)

2.250

0.325

93(23.9)

84(21.3)

2.029

0.363

 G

398(49.1)

440(52.6)

404(51.9)

437(55.5)

 A

412(50.9)

398(47.4)

1.972

0.171

374(48.1)

351(44.5)

1.961

0.161