Association of the SPTLC3 rs364585 polymorphism and serum lipid profiles in two Chinese ethnic groups

Zhang, Qing-Hui; Yin, Rui-Xing; Gao, Hui; Huang, Feng; Wu, Jin-Zhen; Pan, Shang-Ling; Lin, Wei-Xiong; Yang, De-Zhai

doi:10.1186/s12944-016-0392-3

Lipids in Health and Disease

Table 5 The risk factors for serum lipid parameters in the Han and Jing populations

From: Association of the SPTLC3 rs364585 polymorphism and serum lipid profiles in two Chinese ethnic groups

Lipid	Risk factor	B	Std.error	Beta	t	P
Han and Jing
TC	Glucose	0.140	0.016	0.220	8.922	0.000
	Age	0.009	0.002	0.130	4.838	0.000
	Gender	0.198	0.047	0.113	4.206	0.000
	Diastolic blood pressure	0.005	0.002	0.056	2.312	0.021
	Genotype	0.097	0.046	0.050	2.091	0.037
	Pulse pressure	−0.003	0.001	−0.060	−2.233	0.026
	Ethnic group	0.102	0.043	0.058	2.369	0.018
	Alcohol consumption	0.077	0.038	0.055	2.034	0.042
TG	Waist circumference	0.038	0.004	0.406	8.415	0.000
	Cigarette smoking	0.257	0.031	0.211	8.403	0.000
	Glucose	0.071	0.015	0.113	4.784	0.000
	Height	−0.015	0.003	−0.143	−4.952	0.000
	Diastolic blood pressure	0.007	0.002	0.085	3.575	0.000
	Body mass index	−0.029	0.012	−0.109	−2.338	0.020
	Age	−0.003	0.002	−0.053	−2.139	0.033
HDL-C	Waist circumference	−0.017	0.001	−0.321	−12.942	0.000
	Alcohol consumption	0.143	0.021	0.183	6.662	0.000
	Gender	0.193	0.034	0.198	5.602	0.000
	Cigarette smoking	−0.053	0.019	−0.076	−2.717	0.007
	Height	0.008	0.002	0.124	3.641	0.000
	Genotype	−0.070	0.025	−0.065	−2.778	0.006
	Age	0.003	0.001	0.070	2.691	0.007
	Ethnic group	0.061	0.024	0.063	2.590	0.010
LDL-C	Glucose	0.037	0.008	0.116	4.650	0.000
	Genotype	0.123	0.024	0.127	5.223	0.000
	Age	0.003	0.001	0.091	3.658	0.000
	Diastolic blood pressure	0.003	0.001	0.076	3.081	0.002
	Ethnic group	−0.056	0.021	−0.064	−2.611	0.009
ApoA1	Waist circumference	−0.003	0.001	−0.137	−3.059	0.002
	Alcohol consumption	0.077	0.009	0.224	8.472	0.000
	Gender	0.052	0.011	0.121	4.553	0.000
	Glucose	−0.011	0.004	−0.068	−2.818	0.005
	Systolic blood pressure	0.001	0.000	0.067	2.721	0.007
	Body mass index	−0.006	0.003	−0.089	−2.006	0.045
ApoB	Waist circumference	0.005	0.001	0.200	7.974	0.000
	Age	0.002	0.000	0.089	3.364	0.001
	Ethnic group	−0.027	0.012	−0.056	−2.299	0.022
	Systolic blood pressure	0.001	0.000	0.061	2.294	0.022
ApoA1/ApoB	Waist circumference	−0.007	0.002	−0.172	−3.447	0.001
	Glucose	−0.023	0.007	−0.084	−3.485	0.001
	Alcohol consumption	0.065	0.016	0.108	4.112	0.000
	Age	−0.002	0.001	−0.059	−2.241	0.025
	Genotype	−0.049	0.020	−0.058	−2.470	0.014
	Weight	−0.039	0.011	−1.020	−3.672	0.000
	Height	0.029	0.008	0.634	3.801	0.000
	Body mass index	0.082	0.026	0.702	3.145	0.002
	Gender	0.063	0.026	0.084	2.414	0.016
Han
TC	Glucose	0.210	0.027	0.262	7.710	0.000
	Cigarette smoking	−0.117	0.039	−0.101	−3.042	0.002
	Pulse pressure	0.001	0.000	0.072	2.141	0.033
	Systolic blood pressure	0.003	0.002	0.073	2.123	0.034
TG	Waist circumference	0.038	0.006	0.386	6.678	0.000
	Cigarette smoking	0.226	0.041	0.190	5.535	0.000
	Glucose	0.107	0.027	0.131	3.978	0.000
	Diastolic blood pressure	0.007	0.003	0.089	2.639	0.008
	Weight	−0.014	0.005	−0.150	−2.558	0.011
HDL-C	Waist circumference	−0.015	0.002	−0.265	−7.742	0.000
	Cigarette smoking	−0.125	0.028	−0.177	−4.404	0.000
	Alcohol consumption	0.135	0.028	0.196	4.803	0.000
	Gender	0.212	0.051	0.205	4.162	0.000
	Height	0.009	0.003	0.138	3.008	0.003
	Genotype	−0.089	0.038	−0.076	−2.306	0.021
LDL-C	Glucose	0.073	0.014	0.175	5.042	0.000
	Systolic blood pressure	0.003	0.001	0.133	3.853	0.000
	Genotype	0.122	0.033	0.123	3.658	0.000
ApoA1	Alcohol consumption	0.071	0.009	0.264	7.538	0.000
ApoA1	Weight	−0.004	0.001	−0.186	−5.318	0.000
ApoB	Waist circumference	0.005	0.001	0.185	5.415	0.000
	Systolic blood pressure	0.002	0.000	0.132	3.763	0.000
	Glucose	0.019	0.008	0.083	2.393	0.017
ApoA1/ApoB	Body mass index	−0.028	0.004	−0.245	−7.259	0.000
	Glucose	−0.042	0.012	−0.122	−3.570	0.000
	Alcohol consumption	0.063	0.019	0.130	3.376	0.001
	Gender	0.078	0.028	0.107	2.775	0.006
	Systolic blood pressure	−0.002	0.001	−0.080	−2.290	0.022
	Genotype	−0.056	0.027	−0.069	−2.065	0.039
Jing
TC	Glucose	0.103	0.019	0.186	5.414	0.000
	Age	0.017	0.003	0.262	6.767	0.000
	Pulse pressure	−0.008	0.002	−0.151	−4.064	0.000
	Gender	0.348	0.073	0.193	4.754	0.000
	Cigarette smoking	0.198	0.053	0.146	3.767	0.000
	Alcohol consumption	0.296	0.077	0.139	3.825	0.000
	Body mass index	0.056	0.017	0.198	3.257	0.001
	Genotype	0.166	0.066	0.085	2.524	0.012
	Waist circumference	−0.015	0.006	−0.158	−2.539	0.011
	Diastolic blood pressure	0.006	0.003	0.069	1.964	0.050
TG	Waist circumference	0.034	0.003	0.373	10.642	0.000
	Cigarette smoking	0.286	0.045	0.226	6.436	0.000
	Height	−0.016	0.004	−0.149	−4.041	0.000
	Glucose	0.049	0.017	0.096	2.896	0.004
HDL-C	Waist circumference	−0.018	0.002	−0.364	−11.101	0.000
	Alcohol consumption	0.250	0.037	0.232	6.739	0.000
	Gender	0.103	0.032	0.113	3.259	0.001
	Genotype	−0.089	0.032	−0.090	−2.758	0.006
LDL-C	Genotype	0.136	0.033	0.144	4.123	0.000
	Age	0.005	0.001	0.149	4.028	0.000
	Cigarette smoking	0.090	0.026	0.139	3.503	0.000
	Gender	0.080	0.034	0.092	2.308	0.021
	Glucose	0.019	0.009	0.073	2.054	0.040
	Diastolic blood pressure	0.003	0.001	0.071	2.031	0.043
ApoA1	Waist circumference	−0.006	0.001	−0.261	−7.425	0.000
	Alcohol consumption	0.067	0.019	0.127	3.469	0.001
	Gender	0.048	0.016	0.107	2.933	0.003
	Systolic blood pressure	0.001	0.000	0.079	2.278	0.023
ApoB	Waist circumference	0.005	0.001	0.202	5.802	0.000
ApoB	Age	0.002	0.001	0.117	3.348	0.001
ApoA1/ApoB	Waist circumference	−0.008	0.003	−0.196	−3.198	0.001
	Age	−0.003	0.001	−0.122	−3.482	0.001
	Alcohol consumption	0.087	0.031	0.095	2.776	0.006
	Weight	−0.005	0.002	−0.136	−2.187	0.029

TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA1 apolipoprotein A1, ApoB apolipoprotein B, ApoA1/ApoB the ratio of apolipoprotein A1 to apolipoprotein B

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