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Table 1 Advantages and disadvantages of mouse models for studying atherosclerosis

From: Mouse models of atherosclerosis: a historical perspective and recent advances

Advantages Disadvantages
Ease of genetic manipulation Toxic diet needed to induce atherosclerosis in wild-type mice
Low maintenance cost Different lipid metabolism compared to humans: high HDL, no CETP
Short generation time means less time consuming for research projects Differing cardiovascular anatomy and physiology with different predisposed site for the development atherosclerosis
Wide availability Small body size limits frequent blood collection and increases difficulty of dissection of small arteries