From: Mouse models of atherosclerosis: a historical perspective and recent advances
Advantages | Disadvantages |
---|---|
Ease of genetic manipulation | Toxic diet needed to induce atherosclerosis in wild-type mice |
Low maintenance cost | Different lipid metabolism compared to humans: high HDL, no CETP |
Short generation time means less time consuming for research projects | Differing cardiovascular anatomy and physiology with different predisposed site for the development atherosclerosis |
Wide availability | Small body size limits frequent blood collection and increases difficulty of dissection of small arteries |