Fig. 3
Time/dose response of Sch B treatment on serum non-esterified fatty acid (NEFA) and hepatocyte growth factor (HGF) levels. Experimental details were described in Fig. 1. For the time course study, serum NEFA and HGF levels were measured at 12, 24, 48, 72, 96 and 120 after Sch B treatment (a and c). For the dose–response study, mice were intragastrically treated with Sch B (0.25–2 g/kg). Twenty-four 24 h later, the pharmacodynamic parameters (E max, K D, and pD 2) were estimated (b and d). Values given are the mean ± SEM, with n = 10. *P < 0.05, **P < 0.01 vs Control, using a one-way ANOVA followed by Dunnett’s multiple comparisons test, Student’s t-test or post-hoc analysis