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Fig. 8 | Lipids in Health and Disease

Fig. 8

From: Biochemical mechanism underlying hypertriglyceridemia and hepatic steatosis/hepatomegaly induced by acute schisandrin B treatment in mice

Fig. 8

Time/dose response of Sch B treatment on hepatic mass and haematoxylin and eosin (HE) stain. Experimental details were described in Fig. 1. At 24 h after Sch B treatment, mice were sacrificed, and livers were removed and weighed to calculate the hepatic index (hepatic weight/body weight × 100) and pharmacodynamic parameters (E max, K D, and pD 2) shown in (a and b). Then liver samples were fixed in 10% formalin and stained with HE. A representative microscopic picture of a HE-stained liver tissue section for each group is shown in c, and total vacuole area of each section was computed by Image Proplus 6.0 (d). Values given are the mean ± SEM, with n = 10. *P < 0.05, **P < 0.01 vs Control, using a one-way ANOVA follow by Dunnett’s multiple comparisons test, Student’s t-test or post-hoc analysis

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