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Table 2 Mean and SEM values and control adjusted changes for the apolipoproteins ApoB48, ApoC3 and ApoE in serum from the NHPs at baseline and during treatment with the omega-3 rich phospholipid preparation. Dose levels of the administered phospholipids, EPA, DHA and choline are given at the end of the table

From: Effects of a purified krill oil phospholipid rich in long-chain omega-3 fatty acids on cardiovascular disease risk factors in non-human primates with naturally occurring diabetes type-2 and dyslipidemia

Parameter

Group

Value

Baseline

Week after start of treatment

1

2

3

4

5

6

7

8

9

10

11

12

ApoB48 (mg/dL)

Control

Mean

1.84

1.86

1.96

1.77

1.84

1.84

1.97

1.96

1.84

2.00

1.95

1.81

1.93

SEM

0.06

0.05

0.04

0.17

0.12

0.20

0.06

0.07

0.15

0.05

0.08

0.12

0.16

Treated

Mean

2.19

2.42

2.17

2.23

2.37

2.25

2.39

2.42

2.27

2.47

2.22

2.61

2.60

SEM

0.21

0.12

0.31

0.05

0.30

0.19

0.31

0.20

0.15

0.07

0.37

0.15

0.10

Control adjusteda

-

10

−8

7

8

3

1

4

4

5

−7

22

15

ApoC3 (ng/mL)

Control

Mean

50.7

62.3

42.5

37.0

40.9

46.2

48.2

39.9

56.9

44.2

28.9

42.2

38.0

SEM

14.5

10.1

3.17

5.40

10.9

15.1

12.0

17.9

18.3

11.4

11.9

17.9

20.4

Treated

Mean

45.8

33.6

31.3

21.2

21.4

18.7

18.2

13.4

40.7

28.0

30.2

12.5

14.1

SEM

21.9

20.0

18.7

13.2

13.8

10.5

7.70

10.9

21.0

13.4

21.7

4.85

5.42

Control adjusteda

-

−71

−34

−40

−44

−57

−56

−51

−26

−34

−1

−45

−31

ApoE (ng/mL)

Control

Mean

1.06

1.63

1.20

1.23

1.26

1.99

1.15

1.13

1.36

1.36

1.29

1.59

1.32

SEM

0.12

0.24

0.19

0.27

0.07

0.40

0.18

0.10

0.19

0.09

0.17

0.15

0.05

Treated

Mean

1.68

1.84

1.72

1.44

2.12

2.37

1.95

2.72

1.73

2.61

2.88

2.41

2.67

SEM

0.19

0.34

0.27

0.14

0.28

0.62

0.36

0.57

0.30

0.62

0.99

0.50

0.65

Control adjusteda

0

−42

−10

−30

6

−46

10

54

−25

23

70

4

29

Dose (mg phospholipids/kg bw/day)

50

150

450

Dose (mg [EPA/DHA]/kg bw/day)

9.35/5.48

28.0/16.4

84.1/49.3

Dose (mg choline/kg bw/day)

5.83

17.50

52.50

  1. a % change of treated group relative to control group