Parameter | Group | Value | Baseline | Week after start of treatment | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | ||||
ApoB48 (mg/dL) | Control | Mean | 1.84 | 1.86 | 1.96 | 1.77 | 1.84 | 1.84 | 1.97 | 1.96 | 1.84 | 2.00 | 1.95 | 1.81 | 1.93 |
SEM | 0.06 | 0.05 | 0.04 | 0.17 | 0.12 | 0.20 | 0.06 | 0.07 | 0.15 | 0.05 | 0.08 | 0.12 | 0.16 | ||
Treated | Mean | 2.19 | 2.42 | 2.17 | 2.23 | 2.37 | 2.25 | 2.39 | 2.42 | 2.27 | 2.47 | 2.22 | 2.61 | 2.60 | |
SEM | 0.21 | 0.12 | 0.31 | 0.05 | 0.30 | 0.19 | 0.31 | 0.20 | 0.15 | 0.07 | 0.37 | 0.15 | 0.10 | ||
Control adjusteda | - | 10 | −8 | 7 | 8 | 3 | 1 | 4 | 4 | 5 | −7 | 22 | 15 | ||
ApoC3 (ng/mL) | Control | Mean | 50.7 | 62.3 | 42.5 | 37.0 | 40.9 | 46.2 | 48.2 | 39.9 | 56.9 | 44.2 | 28.9 | 42.2 | 38.0 |
SEM | 14.5 | 10.1 | 3.17 | 5.40 | 10.9 | 15.1 | 12.0 | 17.9 | 18.3 | 11.4 | 11.9 | 17.9 | 20.4 | ||
Treated | Mean | 45.8 | 33.6 | 31.3 | 21.2 | 21.4 | 18.7 | 18.2 | 13.4 | 40.7 | 28.0 | 30.2 | 12.5 | 14.1 | |
SEM | 21.9 | 20.0 | 18.7 | 13.2 | 13.8 | 10.5 | 7.70 | 10.9 | 21.0 | 13.4 | 21.7 | 4.85 | 5.42 | ||
Control adjusteda | - | −71 | −34 | −40 | −44 | −57 | −56 | −51 | −26 | −34 | −1 | −45 | −31 | ||
ApoE (ng/mL) | Control | Mean | 1.06 | 1.63 | 1.20 | 1.23 | 1.26 | 1.99 | 1.15 | 1.13 | 1.36 | 1.36 | 1.29 | 1.59 | 1.32 |
SEM | 0.12 | 0.24 | 0.19 | 0.27 | 0.07 | 0.40 | 0.18 | 0.10 | 0.19 | 0.09 | 0.17 | 0.15 | 0.05 | ||
Treated | Mean | 1.68 | 1.84 | 1.72 | 1.44 | 2.12 | 2.37 | 1.95 | 2.72 | 1.73 | 2.61 | 2.88 | 2.41 | 2.67 | |
SEM | 0.19 | 0.34 | 0.27 | 0.14 | 0.28 | 0.62 | 0.36 | 0.57 | 0.30 | 0.62 | 0.99 | 0.50 | 0.65 | ||
Control adjusteda | 0 | −42 | −10 | −30 | 6 | −46 | 10 | 54 | −25 | 23 | 70 | 4 | 29 | ||
Dose (mg phospholipids/kg bw/day) | 50 | 150 | 450 | ||||||||||||
Dose (mg [EPA/DHA]/kg bw/day) | 9.35/5.48 | 28.0/16.4 | 84.1/49.3 | ||||||||||||
Dose (mg choline/kg bw/day) | 5.83 | 17.50 | 52.50 |