Table 4 Mean and SEM values for the safety parameters measured in the control and treated groups at baseline and during the 12 week treatment period. Dose levels of phospholipids, EPA, DHA and choline are given at the end of the table

Alanine transaminase (ALT) (U/L)

Control

Mean

128

127

182

101

SEM

59

54

103

32

Treated

Mean

86

87

65

75

SEM

50

24

2

14

Aspartate Aminotransferase (AST) (U/L)

Control

Mean

36

32

44

33

SEM

6

4

13

4

Treated

Mean

32

27

30

42

SEM

9

5

6

11

Alkaline Phosphatase (ALP) (U/L)

Control

Mean

225

221

226

220

SEM

37

40

46

56

Treated

Mean

162

166

140

169

SEM

37

44

36

68

Blood Urea Nitrogen (BUN) (mmol/L)

Control

Mean

6.69

6.13

6.46

6.29

SEM

0.46

0.69

0.67

0.69

Treated

Mean

6.16

5.65

5.95

5.65

SEM

0.04

0.52

0.63

0.54

Creatinine (μmol/L)

Control

Mean

62

64

63

61

SEM

23

23

23

23

Treated

Mean

77

74

80

76

SEM

5.2

5.6

5.3

5.4

Uric acid (μmol/L)

Control

Mean

6.07

4.90

5.37

6.40

SEM

0.17

0.12

0.12

0.25

Treated

Mean

7.00

9.17

6.70

7.13

SEM

1.04

2.99

1.17

1.33

Cystatin C (mg/L)

Control

Mean

1.23

1.17

1.15

1.10

SEM

0.21

0.23

0.22

0.16

Treated

Mean

1.21

1.23

1.26

1.24

SEM

0.01

0.10

0.10

0.10

Prothromin time (PT) (sec)

Control

Mean

9.90

9.8

10.5

10.6

SEM

0.36

0.40

0.52

0.64

Treated

Mean

10.1

10.0

10.6

10.8

SEM

0.29

0.36

0.32

0.20

Activated Partial Thromboplastin time (APTT) (sec)

Control

Mean

19.3

19.7

19.1

18.9

SEM

0.18

0.47

0.73

1.22

Treated

Mean

21.0

21.9

21.5

21.5

SEM

1.93

1.85

2.18

2.55

Thrombin Time (TT) (sec)

Control

Mean

30.5

29.8

27.9

26.8

SEM

0.52

1.73

1.54

2.18

Treated

Mean

29.3

28.8

28.7

28.1

SEM

0.92

2.80

1.91

1.34

50

150

450

9.35/5.48

28.1/16.4

84.2/49.3

5.83

17.5

52.5