|
Alanine transaminase (ALT) (U/L)
|
Control
|
Mean
|
128
|
127
|
182
|
101
|
|
SEM
|
59
|
54
|
103
|
32
|
|
Treated
|
Mean
|
86
|
87
|
65
|
75
|
|
SEM
|
50
|
24
|
2
|
14
|
|
Aspartate Aminotransferase (AST) (U/L)
|
Control
|
Mean
|
36
|
32
|
44
|
33
|
|
SEM
|
6
|
4
|
13
|
4
|
|
Treated
|
Mean
|
32
|
27
|
30
|
42
|
|
SEM
|
9
|
5
|
6
|
11
|
|
Alkaline Phosphatase (ALP) (U/L)
|
Control
|
Mean
|
225
|
221
|
226
|
220
|
|
SEM
|
37
|
40
|
46
|
56
|
|
Treated
|
Mean
|
162
|
166
|
140
|
169
|
|
SEM
|
37
|
44
|
36
|
68
|
|
Blood Urea Nitrogen (BUN) (mmol/L)
|
Control
|
Mean
|
6.69
|
6.13
|
6.46
|
6.29
|
|
SEM
|
0.46
|
0.69
|
0.67
|
0.69
|
|
Treated
|
Mean
|
6.16
|
5.65
|
5.95
|
5.65
|
|
SEM
|
0.04
|
0.52
|
0.63
|
0.54
|
|
Creatinine (μmol/L)
|
Control
|
Mean
|
62
|
64
|
63
|
61
|
|
SEM
|
23
|
23
|
23
|
23
|
|
Treated
|
Mean
|
77
|
74
|
80
|
76
|
|
SEM
|
5.2
|
5.6
|
5.3
|
5.4
|
|
Uric acid (μmol/L)
|
Control
|
Mean
|
6.07
|
4.90
|
5.37
|
6.40
|
|
SEM
|
0.17
|
0.12
|
0.12
|
0.25
|
|
Treated
|
Mean
|
7.00
|
9.17
|
6.70
|
7.13
|
|
SEM
|
1.04
|
2.99
|
1.17
|
1.33
|
|
Cystatin C (mg/L)
|
Control
|
Mean
|
1.23
|
1.17
|
1.15
|
1.10
|
|
SEM
|
0.21
|
0.23
|
0.22
|
0.16
|
|
Treated
|
Mean
|
1.21
|
1.23
|
1.26
|
1.24
|
|
SEM
|
0.01
|
0.10
|
0.10
|
0.10
|
|
Prothromin time (PT) (sec)
|
Control
|
Mean
|
9.90
|
9.8
|
10.5
|
10.6
|
|
SEM
|
0.36
|
0.40
|
0.52
|
0.64
|
|
Treated
|
Mean
|
10.1
|
10.0
|
10.6
|
10.8
|
|
SEM
|
0.29
|
0.36
|
0.32
|
0.20
|
|
Activated Partial Thromboplastin time (APTT) (sec)
|
Control
|
Mean
|
19.3
|
19.7
|
19.1
|
18.9
|
|
SEM
|
0.18
|
0.47
|
0.73
|
1.22
|
|
Treated
|
Mean
|
21.0
|
21.9
|
21.5
|
21.5
|
|
SEM
|
1.93
|
1.85
|
2.18
|
2.55
|
|
Thrombin Time (TT) (sec)
|
Control
|
Mean
|
30.5
|
29.8
|
27.9
|
26.8
|
|
SEM
|
0.52
|
1.73
|
1.54
|
2.18
|
|
Treated
|
Mean
|
29.3
|
28.8
|
28.7
|
28.1
|
|
SEM
|
0.92
|
2.80
|
1.91
|
1.34
|
|
Dose (mg phospholipids/kg bw/day)
|
50
|
150
|
450
|
|
Dose (mg [EPA/DHA]/kg bw/day)
|
9.35/5.48
|
28.1/16.4
|
84.2/49.3
|
|
Dose (mg choline/kg bw/day)
|
5.83
|
17.5
|
52.5
|
