SLC12A3 variants modulate LDL cholesterol levels in the Mongolian population

Table 1 Effects of demographic, lifestyle characteristics and other non-genetic factors on individuals’ serum lipid levels

Variables ^a	n	TCHO (mmol/L)	TG (mmol/L)	HDL-c (mmol/L)	LDL-c (mmol/L)
Age (years)
≤ 45	171	4.76 ± 1.77	1.51 ± 1.26	1.49 ± 0.58	3.01 ± 1.32
> 45	160	5.08 ± 2.06	1.98 ± 2.42*	1.43 ± 0.55	3.25 ± 1.33
Sex
Male	139	5.17 ± 1.89***	2.00 ± 2.00**	1.45 ± 0.58	3.34 ± 1.34**
Female	192	4.67 ± 1.71	1.58 ± 1.36	1.45 ± 0.47	2.98 ± 1.28
Smoker
Never	253	4.85 ± 1.92	1.68 ± 2.03	1.47 ± 0.54	3.05 ± 1.30
Smoker	67	5.31 ± 1.96	1.95 ± 1.49	1.47 ± 0.66	3.52 ± 1.37**
Unknown	11	-	-	-	-
Drink
Never	241	4.75 ± 1.76	1.59 ± 1.43	1.44 ± 0.53	3.03 ± 1.30
Drinker	68	5.63 ± 2.44**	2.39 ± 3.17**	1.55 ± 0.74	3.54 ± 1.44*
Unknown	22	-	-	-	-
Blood_G (mg/ml)
≤5.7	160	4.38 ± 1.71	1.50 ± 2.10	1.32 ± 0.47	2.79 ± 1.16
>5.7	147	5.47 ± 2.00***	1.99 ± 1.67*	1.61 ± 0.65***	3.44 ± 1.39***
Unknown	24	-	-	-	-
Heart_R (min⁻¹)
≤ 76	143	5.28 ± 2.11*	1.85 ± 2.25	1.58 ± 0.65*	3.30 ± 1.37
> 76	122	4.75 ± 1.89	1.72 ± 1.65	1.41 ± 0.54	3.07 ± 1.32
Unknown	66	-	-	-	-
BMI (kg/m²)
≤ 24.44	166	4.84 ± 1.95	1.40 ± 1.20	1.60 ± 0.63***	2.91 ± 1.35
> 24.44	162	4.97 ± 1.91	2.07 ± 2.39**	1.32 ± 0.47	3.33 ± 1.27**
Unknown	3	-	-	-	-
WHR
≤ 0.87	132	4.82 ± 2.07	1.40 ± 1.20	1.54 ± 0.68	3.00 ± 1.35
> 0.87	128	5.23 ± 2.00	2.27 ± 2.53***	1.42 ± 0.54	3.36 ± 1.36*
Unknown	71	-	-	-	-

*** p value < 0.001; ** p value < 0.01; * p value < 0.05
Abbreviation BMI body mass index, WHR waist-hip ratio, Blood_G fasting blood glucose in serum, Heart_R heart rate per minute, TCHO total cholesterol (mmol/L), TG triglycerides (mmol/L), HDL-C high-density lipoprotein cholesterol (mmol/L), LDL-C low-density lipoprotein cholesterol (mmol/L)
^aall variables were categorized by the median value in study sample

ISSN: 1476-511X