Table 2 Concentrations (pmol/ml) of the endocannabinoid-type compounds measured in plasma from the non-human primates (n = 3 in each of the two groups) at baseline, during and after treatment with increasing doses of the omega-3 rich phospholipid preparation

Anandamide

Control

Mean

4.24

4.80

5.60

4.31

4.82

4.66

6.02

6.19

2.82

5.19

5.15

SEM

2.00

1.18

2.17

0.93

0.80

0.91

3.84

2.65

0.77

1.38

1.67

Treated

Mean

3.07

3.40

2.86

2.98

2.86

3.34

2.28

3.64

4.25

4.05

4.44

SEM

0.52

1.54

0.93

0.56

0.92

1.35

0.97

1.35

1.69

1.53

0.43

2-arachidonoylglycerol

Control

Mean

14.3

21.0

23.1

21.9

27.8

20.7

28.6

22.7

19.0

18.6

22.4

SEM

5.5

13.8

15.9

11.1

19.2

15.2

20.6

12.3

11.8

11.3

15.5

Treated

Mean

16.8

19.2

13.3

9.14

11.7

4.42

8.48

15.0

26.5

16.5

26.4

SEM

6.4

9.2

7.9

1.12

3.3

1.60

4.20

10.0

19.1

9.1

11.3

EPA ethanolamide

Control

Mean

1.36

1.45

0.91

1.25

0.22

0.57

1.00

1.07

2.07

2.04

2.84

SEM

0.49

0.29

0.16

0.31

0.07

0.20

0.07

0.71

0.84

0.62

1.06

Treated

Mean

0.47

1.04

1.05

1.13

0.85

1.00

1.07

0.58

1.34

1.55

0.63

SEM

0.13

0.48

0.34

0.26

0.24

0.17

0.26

0.22

0.93

0.51

0.35

DHA ethanolamide

Control

Mean

1.23

4.67

5.17

6.64

4.95

4.63

4.61

2.28

3.89

5.82

4.80

SEM

0.29

1.35

2.09

1.95

2.45

2.03

2.06

1.10

1.45

2.49

1.91

Treated

Mean

3.06

6.63

8.03

7.24

6.60

7.41

4.96

3.49

5.57

5.97

6.76

SEM

1.68

3.17

2.34

1.52

1.59

1.12

0.89

0.39

1.30

2.83

2.93

Palmitoyl ethanolamide

Control

Mean

54.7

64.7

58.3

94.7

53.5

71.9

89.9

30.8

24.7

59.3

120

SEM

4.70

10.3

15.3

30.5

12.7

11.2

7.80

4.70

1.50

20.8

36.3

Treated

Mean

66.2

62.5

65.6

86.1

58.6

48.4

69.1

78.8

39.5

92.0

120

SEM

19.2

11.9

14.7

17.3

13.9

9.20

2.40

23.7

8.3

31.5

47.9

Oleoyl ethanolamide

Control

Mean

24.2

24.3

19.0

20.3

30.5

28.5

14.0

29.1

17.6

29.3

31.0

SEM

4.44

1.50

2.25

2.23

1.55

2.65

1.35

5.26

4.10

4.60

2.28

Treated

Mean

24.2

22.3

16.0

20.3

24.8

29.9

14.4

36.9

18.0

39.7

45.5

SEM

3.63

6.86

2.05

2.49

6.63

7.76

2.54

15.01

3.03

14.54

9.89