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Table 2 Concentrations (pmol/ml) of the endocannabinoid-type compounds measured in plasma from the non-human primates (n = 3 in each of the two groups) at baseline, during and after treatment with increasing doses of the omega-3 rich phospholipid preparation

From: The time course of erythrocyte membrane fatty acid concentrations during and after treatment of non-human primates with increasing doses of an omega-3 rich phospholipid preparation derived from krill-oil

Endocannabinoid-type compound Group Value Baseline Week after start of treatment
2 4 6 8 10 12 14 16 18 20
Anandamide Control Mean 4.24 4.80 5.60 4.31 4.82 4.66 6.02 6.19 2.82 5.19 5.15
SEM 2.00 1.18 2.17 0.93 0.80 0.91 3.84 2.65 0.77 1.38 1.67
Treated Mean 3.07 3.40 2.86 2.98 2.86 3.34 2.28 3.64 4.25 4.05 4.44
SEM 0.52 1.54 0.93 0.56 0.92 1.35 0.97 1.35 1.69 1.53 0.43
2-arachidonoylglycerol Control Mean 14.3 21.0 23.1 21.9 27.8 20.7 28.6 22.7 19.0 18.6 22.4
SEM 5.5 13.8 15.9 11.1 19.2 15.2 20.6 12.3 11.8 11.3 15.5
Treated Mean 16.8 19.2 13.3 9.14 11.7 4.42 8.48 15.0 26.5 16.5 26.4
SEM 6.4 9.2 7.9 1.12 3.3 1.60 4.20 10.0 19.1 9.1 11.3
EPA ethanolamide Control Mean 1.36 1.45 0.91 1.25 0.22 0.57 1.00 1.07 2.07 2.04 2.84
SEM 0.49 0.29 0.16 0.31 0.07 0.20 0.07 0.71 0.84 0.62 1.06
Treated Mean 0.47 1.04 1.05 1.13 0.85 1.00 1.07 0.58 1.34 1.55 0.63
SEM 0.13 0.48 0.34 0.26 0.24 0.17 0.26 0.22 0.93 0.51 0.35
DHA ethanolamide Control Mean 1.23 4.67 5.17 6.64 4.95 4.63 4.61 2.28 3.89 5.82 4.80
SEM 0.29 1.35 2.09 1.95 2.45 2.03 2.06 1.10 1.45 2.49 1.91
Treated Mean 3.06 6.63 8.03 7.24 6.60 7.41 4.96 3.49 5.57 5.97 6.76
SEM 1.68 3.17 2.34 1.52 1.59 1.12 0.89 0.39 1.30 2.83 2.93
Palmitoyl ethanolamide Control Mean 54.7 64.7 58.3 94.7 53.5 71.9 89.9 30.8 24.7 59.3 120
SEM 4.70 10.3 15.3 30.5 12.7 11.2 7.80 4.70 1.50 20.8 36.3
Treated Mean 66.2 62.5 65.6 86.1 58.6 48.4 69.1 78.8 39.5 92.0 120
SEM 19.2 11.9 14.7 17.3 13.9 9.20 2.40 23.7 8.3 31.5 47.9
Oleoyl ethanolamide Control Mean 24.2 24.3 19.0 20.3 30.5 28.5 14.0 29.1 17.6 29.3 31.0
SEM 4.44 1.50 2.25 2.23 1.55 2.65 1.35 5.26 4.10 4.60 2.28
Treated Mean 24.2 22.3 16.0 20.3 24.8 29.9 14.4 36.9 18.0 39.7 45.5
SEM 3.63 6.86 2.05 2.49 6.63 7.76 2.54 15.01 3.03 14.54 9.89
Dose (mg phospholipids/kg bw/day) 50 150 450 0
Dose (mg [EPA/DHA]/kg bw/day) 9.35/5.48 28.0/16.4 84.1/49.3 0/0
  1. Doses of phospholipids and of EPA and DHA are shown at the end of the table