The effects of short-term high-fat feeding on exercise capacity: multi-tissue transcriptome changes by RNA sequencing analysis

Xiao, Ya; Wang, Wanshan; Chen, Liguo; Chen, Jieyu; Jiang, Pingping; Fu, Xiuqiong; Nie, Xiaoli; Kwan, Hiuyee; Liu, Yanyan; Zhao, Xiaoshan

doi:10.1186/s12944-017-0424-7

Lipids in Health and Disease

Table 3 Differentially expressed genes in the brain of HFD-fed mice

From: The effects of short-term high-fat feeding on exercise capacity: multi-tissue transcriptome changes by RNA sequencing analysis

Gene symbol	Log₂FC	P- value	Gene symbol	Log₂FC	P- value	Gene symbol	Log₂FC	P- value
Alpi	−3.65	0.022	Slc22a19	−3.40	0.008	Gm13986	−2.48	0.019
Alpk3	−6.59	0.009	Sly	−6.59	0.009	Gm14302	−6.28	0.016
Bhlha15	−3.52	0.027	Smim24	−3.65	0.022	Gm14673	−2.43	0.018
Bmp8b	−1.82	0.039	Spata18	−5.87	0.048	Gm14886	−6.02	0.033
Brs3	2.80	0.034	Tfap2a	−2.26	0.033	Gm15174	−2.49	0.036
C6	−6.15	0.023	Tnfsf15	−5.87	0.048	Gm15302	−5.87	0.048
C87414	−5.87	0.048	Uncx	−2.43	0.041	Gm15839	−1.96	0.047
Capn11	−2.98	0.010	Usp17la	−1.86	0.039	Gm16028	−6.15	0.023
Ccr1	3.72	0.046	Vax2os	−2.15	0.017	Gm16060	−5.87	0.048
Ccr4	−3.05	0.008	Zfp345	−2.89	0.032	Gm16513	−5.87	0.048
Cd200r3	−1.97	0.040	1700007P06Rik	−6.02	0.033	Gm17085	−3.94	0.011
Cd274	−1.80	0.037	1700021A07Rik	−3.38	0.042	Gm17535	−7.89	5.53E-09
Cd300lg	−3.58	0.005	1700128F08Rik	−2.23	0.012	Gm20505	−2.04	0.046
Ces5a	−1.83	0.034	1810019N24Rik	−6.02	0.033	Gm20663	−1.98	0.044
Cpa4	−5.87	0.048	2810404F17Rik	−4.30	4.67E-04	Gm20831	−6.69	0.006
Csprs	−3.38	0.042	3110067C02Rik	−5.87	0.048	Gm21292	−3.39	0.003
Dsg3	−2.23	0.022	4931406B18Rik	−1.69	0.050	Gm2165	−2.71	0.020
Egfros	−6.39	0.016	9530056K15Rik	−5.87	0.048	Gm21719	−6.15	0.023
Esp6	−6.86	0.005	C230088H06Rik	−4.17	0.005	Gm21738	−6.61	2.23E-09
Ffar2	−3.38	0.042	C430042M11Rik	−3.06	0.002	Gm21776	−6.69	0.006
Gcm1	−2.38	0.013	G430049J08Rik	−2.29	0.025	Gm21784	−3.77	0.015
Hopxos	−5.87	0.048	CH36-246D16.4	−3.02	0.009	Gm21989	6.03	0.048
Hoxd11	−3.61	3.48E-04	CH36-35H7.2	−7.54	0.001	Gm23897	−2.55	0.009
Insrr	−2.45	0.010	CH36-399D20.1	−7.93	1.73E-04	Gm26573	−7.72	3.41E-04
Itgb6	−3.28	0.001	Gm10038	−2.16	0.026	Gm26583	−6.15	0.023
Klk14	−3.48	0.002	Gm10132	−6.02	0.033	Gm26648	−6.28	0.016
Lmx1b	−3.02	0.003	Gm10134	−1.96	0.036	Gm26704	−5.05	9.17E-06
Lypd8	−4.17	0.005	Gm10172	−2.31	0.013	Gm26705	−2.22	0.017
Mep1b	−2.76	0.020	Gm10715	−6.88	1.29E-09	Gm26719	−2.84	0.015
Mid1	−1.78	0.045	Gm10717	−6.11	3.59E-09	Gm26763	−6.15	0.023
Mpz	−5.87	0.048	Gm10718	−6.15	2.98E-09	Gm26804	−7.01	0.003
Ms4a4b	−7.01	0.003	Gm10719	−6.56	5.50E-10	Gm26857	−2.14	0.022
Muc19	−2.46	0.011	Gm10720	−4.94	1.06E-06	Gm26870	−6.03	4.96E-09
Muc6	−5.87	0.048	Gm10721	−8.04	1.26E-04	Gm27956	−6.39	0.016
Mylk4	−2.85	0.002	Gm10722	−5.19	7.91E-07	Gm3755	−1.96	0.036
Nkapl	−2.72	0.046	Gm10800	−6.03	4.95E-09	RP23-184B11.4	−6.28	0.016
Nkx2-1	−3.40	2.13E-04	Gm10801	−5.91	8.73E-09	RP23-315H12.7	−5.87	0.048
Orly	−6.69	0.006	Gm11168	−5.67	3.66E-08	RP23-458B6.16	−6.86	0.005
Otc	2.70	0.032	Gm11231	−2.18	0.032	RP23-91 L14.2	−6.59	0.009
Patl2	−5.87	0.048	Gm11398	−5.87	0.048	RP24-112B7.3	−3.24	0.012
Pcdh12	2.83	0.046	Gm11883	−5.87	0.048	RP24-209E1.3	−6.02	0.033
Pou1f1	−2.62	0.003	Gm11948	−5.87	0.048	RP24-228I22.1	−6.69	0.006
Pou2f2	−1.83	0.043	Gm12177	−2.43	0.021	RP24-319B23.2	−4.68	0.001
Pou2f3-rs1	−6.02	0.033	Gm12496	−2.91	0.013	RP24-369 J17.1	−6.39	0.016
Psg28	−1.83	0.042	Gm12652	−6.28	0.016	RP24-446E18.2	−6.02	0.033
Rbp2	−3.72	0.018	Gm13086	−2.34	0.023	RP24-482E11.1	−5.87	0.048
Rdh19	−6.28	0.016	Gm13465	−2.54	0.033	RP24-72B9.10	−6.02	0.033
Rhox8	−6.15	0.023	Gm13691	−6.28	0.016
Serpina10	−4.52	0.002	Gm13961	−5.87	0.048

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