Does a lack of physical activity explain the rheumatoid arthritis lipid profile?

AbouAssi, Hiba; Connelly, Margery A.; Bateman, Lori A.; Tune, K. Noelle; Huebner, Janet L.; Kraus, Virginia B.; Winegar, Deborah A.; Otvos, James D.; Kraus, William E.; Huffman, Kim M.

doi:10.1186/s12944-017-0427-4

Lipids in Health and Disease

Table 2 Relationships between lipoprotein parameters and various measures in persons with RA (n = 50)

From: Does a lack of physical activity explain the rheumatoid arthritis lipid profile?

	Total LDL-P	Large LDL-P	Small LDL-P	LDL Size	LDL-C	Total HDL-P	Large HDL-P	Medium HDL-P	Small HDL-P	HDL Size	HDL-C
Disease Activity
Disability (HAQ-DI)	−0.10	0.11	−0.19	0.10	−0.10	−0.25	0.10	−0.02	−0.37 ^†	0.20	−0.10
Pain (VAS) (mm)	−0.15	−0.06	−0.13	−0.06	−0.07	−0.32 ^†	−0.03	0.02	−0.42 ^‡	0.11	−0.20
Disease activity (DAS_ESR-28)	0.00	0.08	0.05	−0.04	−0.03	−0.20	−0.02	0.03	−0.26	0.06	−0.19
ESR (mm/h)	−0.08	−0.03	0.06	−0.10	−0.13	−0.02	−0.05	0.12	−0.08	−0.01	−0.09
hsCRP (mg/L)	−0.05	−0.14	0.14	−0.24	−0.04	−0.22	−0.12	−0.04	−0.07	−0.08	−0.18
IL-1β (pg/ml)	−0.15	−0.14	0.00	−0.12	−0.02	−0.02	−0.11	0.19	−0.15	−0.04	−0.00
IL-6 (pg/ml)	−0.07	−0.17	0.09	−0.31 ^†	−0.27	−0.12	−0.06	−0.07	0.01	−0.12	−0.21
IL-18 (pg/ml)	0.16	−0.23	0.26	−0.33 ^†	−0.23	−0.05	−0.26	−0.08	0.19	−0.26	−0.03
TNF-α (pg/ml)	0.26	−0.07	0.23	−0.28 ^†	−0.30 ^†	−0.26	−0.23	−0.31 ^†	0.14	−0.24	−0.04
Body Composition
Body mass index (kg/m²)	0.37 ^†	0.01	0.33 ^†	−0.08	0.32 ^†	−0.14	−0.38 ^†	−0.23	0.24	−0.32 ^†	−0.22
Waist circumference (cm)	0.39 ^†	−0.03	0.37 ^†	−0.14	0.23	−0.13	−0.44 ^‡	−0.22	0.29 ^†	−0.42 ^‡	−0.29 ^†
Abdominal visceral adiposity (cm²)	0.47 ^‡	0.13	0.32 ^†	−0.07	0.38 ^†	−0.04	−0.41 ^‡	−0.05	0.21	−0.39 ^†	−0.17
Abdominal subcutaneous adiposity (cm²)	0.20	0.01	0.16	0.05	0.17	−0.07	−0.24	−0.14	0.14	−0.20	−0.08
Insulin Action
Insulin sensitivity (×10⁻⁵ min¹/[pmol/L])	−0.28	0.17	−0.30	0.32 ^†	0.18	0.39 ^†	0.25	0.24	0.12	0.20	0.31 ^†
HOMA-IR	0.37 ^†	−0.26	0.53 ^‡	−0.53 ^‡	0.06	−0.22	−0.54 ^‡	−0.24	0.24	−0.53 ^‡	−0.51 ^‡
Fasting insulin (mU/L)	0.34 ^†	−0.25	0.43 ^‡	−0.45 ^‡	0.30 ^†	−0.29	−0.48 ^‡	−0.31 ^†	0.18	−0.46 ^‡	−0.47 ^‡
Physical Activity (n = 41)
Basal activity (% min)	−0.29	0.19	−0.48 ^‡	0.33 ^†	−0.12	−0.31 ^†	0.37 ^†	−0.02	−0.52 ^‡	0.43 ^‡	0.23
Exercise (% min)	0.18	−0.24	0.41 ^†	−0.32 ^†	−0.02	0.22	−0.37 ^†	0.05	0.37 ^†	−0.43 ^‡	−0.30

HAQ-DI Health Assessment Questionnaire Disability Index, VAS visual analogue scale, DAS _ESR -28 Disease activity score with 28 joint count using erythrocyte sedimentation rate (ESR), hsCRP High sensitivity C-reactive protein, HOMA-IR Homeostatic model assessment of insulin resistance, LDL-P Low density lipoprotein particles, LDL-C Low density lipoprotein cholesterol, HDL-P High density lipoprotein particles, HDL-C High density lipoprotein cholesterol, RA Rheumatoid arthritis
Data are shown as Spearman correlation coefficients (r). ^†0.005 < P < 0.05 ^‡ P ≤ 0.005

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