Table 2 Hormonal, metabolic and oxidative stress parameters and PAF-AH activities in PCOS patients and control women
|  | Controls (n = 501) | PCOS (n = 565) | P | P a |
|---|---|---|---|---|
Age (years) | 27.93 ± 4.20 | 24.69 ± 3.90 | 0.000 |  |
BMI (kg/m2) | 21.07 ± 2.89 | 23.08 ± 4.24 | 0.000 |  |
Hormonal levels | ||||
 E2 (pmol/L) | 331.82 ± 350.14 | 286.60 ± 272.76 | 0.027 | 0.587 |
 TT (nmol/L) | 1.53 ± 0.56 | 2.43 ± 0.76 | 0.000 | 0.000 |
 LH (IU/L) | 8.63 ± 10.94 | 13.93 ± 10.97 | 0.000 | 0.000 |
 FSH (IU/L) | 6.67 ± 2.97 | 5.99 ± 2.25 | 0.000 | 0.018 |
 LH/FSH | 1.30 ± 1.31 | 2.36 ± 1.27 | 0.000 | 0.000 |
Metabolic profile and oxidative stress parameters | ||||
 Fasting Ins (pmol/L) | 66.12 ± 35.49 | 105.43 ± 72.16 | 0.000 | 0.000 |
 Fasting Glu (mmol/L) | 5.30 ± 0.74 | 5.37 ± 0.78 | 0.108 | 0.473 |
 HOMA-IR | 2.32 ± 1.85 | 3.77 ± 3.13 | 0.000 | 0.001 |
 TG (mmol/L) | 1.04 ± 0.90 | 1.43 ± 1.37 | 0.000 | 0.000 |
 TC (mmol/L) | 4.24 ± 0.70 | 4.41 ± 0.81 | 0.000 | 0.000 |
 HDL-C (mmol/L) | 1.51 ± 0.32 | 1.38 ± 0.35 | 0.000 | 0.008 |
 LDL-C (mmol/L) | 2.34 ± 0.61 | 2.55 ± 0.76 | 0.000 | 0.000 |
 ApoA1 (g/L) | 1.45 ± 0.21 | 1.41 ± 0.21 | 0.005 | 0.772 |
 ApoB (g/L) | 0.75 ± 0.17 | 0.82 ± 0.20 | 0.000 | 0.000 |
 TOS (nmol H2O2 Equiv./mL) | 11.20 ± 5.31 | 14.96 ± 10.81 | 0.000 | 0.000 |
 T-AOC (U/ml/min) | 14.54 ± 2.67 | 15.81 ± 3.07 | 0.000 | 0.000 |
 OSI | 0.80 ± 0.40 | 1.00 ± 0.80 | 0.000 | 0.000 |
 MDA (nmol/ml) | 3.65 ± 1.08 | 4.36 ± 1.13 | 0.000 | 0.000 |
PAF-AH activities and frequencies of PAF-AH G449T genotypea | ||||
 Plasma PAF-AH (nmol/min/ml) | 48.34 ± 10.81 | 47.44 ± 12.94 | 0.371 | 0.741 |
 H-PAF-AH (nmol/min/ml) | 5.11 ± 1.48 | 4.66 ± 1.91 | 0.002 | 0.038 |
 ApoB-PAF-AH (nmol/min/ml) | 43.25 ± 9.96 | 42.77 ± 11.89 | 0.625 | 0.976 |
 ApoB-PAF-AH/H-PAF-AH | 8.88 ± 2.47 | 10.04 ± 3.89 | 0.000 | 0.000 |
  PAF-AH G449T, n (%) | ||||
   GG | 255 (92.7%) | 243 (86.5%) |  |  |
   GT + TT | 20 + 0 (7.3%) | 34 + 4 (13.5%) | 0.020 |  |