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Table 4 Oxidative stress parameters and PAF-AH activities according to PAF-AH R92H genotype in PCOS patients and control women

From: Effect of the R92H and A379V genotypes of platelet-activating factor acetylhydrolase on its enzyme activity, oxidative stress and metabolic profile in Chinese women with polycystic ovary syndrome

 

Controls

 

PCOS

 

RR (n = 335)

RH + HH (n = 151 + 15)

RR (n = 357)

RH + HH (n = 186 + 22)

Age (yr)

28.10 ± 4.23

27.58 ± 4.12

24.98 ± 3.29

24.20 ± 3.81a

BMI (kg/m2)

21.14 ± 3.05

20.92 ± 2.53

23.09 ± 4.33

23.07 ± 4.10

Oxidative stress parameters

 TOS (nmol H2O2 Equiv./mL)

11.27 ± 5.49

10.99 ± 4.92

15.42 ± 11.83

14.17 ± 8.88

 T-AOC (U/ml/min)

14.38 ± 2.58

14.85 ± 2.84

15.84 ± 3.21

15.80 ± 2.83

 OSI

0.81 ± 0.42

0.76 ± 0.37

1.02 ± 0.84

0.95 ± 0.72

 MDA (nmol/ml)

3.67 ± 1.10

3.61 ± 1.04

4.31 ± 1.25

4.42 ± 1.14

PAF-AH activities and frequencies of PAF-AH G449T genotype*

 Plasma PAF-AH (nmol/min/ml)

48.02 ± 11.14

48.90 ± 10.26

46.30 ± 13.32

49.37 ± 12.08a

 H-PAF-AH (nmol/min/ml)

5.04 ± 1.41

5.25 ± 1.59

4.51 ± 1.75

4.92 ± 2.14

 ApoB-PAF-AH (nmol/min/ml)

42.98 ± 10.31

43.64 ± 9.37

41.79 ± 12.23

44.45 ± 11.14a

 ApoB-PAF-AH/H-PAF-AH

8.94 ± 2.60

8.77 ± 2.25

10.15 ± 4.37

9.85 ± 2.95

  PAF-AH G449T, n (%)

   GG

158 (90.8%)

97 (96.0%)

150 (84.7%)

93 (89.4%)

   GT + TT

16 + 0 (9.2%)

4 + 0 (4.0%)

23 + 4 (15.3%)

11 + 0 (10.6%)

  1. Values are presented as the mean ± SD
  2. TOS total oxidant status, T-AOC total antioxidant capacity, OSI oxidative stress index, PAF-AH platelet activating factor acetylhydrolase, H-PAF-AH HDL-associated PAF-AH, ApoB-PAF-AH apolipoprotein B-containing lipoprotein-associated PAF-AH
  3. Comparisons of oxidative stress parameters and PAF-AH activities were corrected for differences in age and BMI between the two groups
  4. a P < 0.05, compared with RR genotype subgroup in PCOS patient
  5. *Controls: RR (n = 174), RH + HH (n = 88 + 13); PCOS: RR (n = 177), RH + HH (n = 98 + 6)