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Table 3 Fatty acid composition of erythrocyte phospholipids from control mice and high-fat diet (HFD) fed mice receiving hydroxytyrosol (HT) supplementation

From: Hydroxytyrosol prevents reduction in liver activity of Δ-5 and Δ-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice

  Fatty acid composition (g/100 g FAME)
  Groups
  Control diet (CD) High fat diet (HFD)
  Saline HT Saline HT
Fatty acid (a) (b) (c) (d)
C16:0 34.5 ± 3.1c 31.9 ± 2.9c 41.6 ± 3.8a,b,d 36.6 ± 3.5c
C18:0 3.62 ± 0.3c,d 3.45 ± 0.4c,d 6.58 ± 0.7a,b 5.58 ± 0.6a,b
C18:1n-9 24.6 ± 1.9 25.6 ± 2.2 22.9 ± 2.3 24.8 ± 2.5
C18:2n-6 (LA) 9.91 ± 1.2 10.2 ± 0.9 8.66 ± 1.7 9.52 ± 1.5
C18:3n-3 (ALA) 1.21 ± 0.5 1.12 ± 0.3 1.05 ± 0.3 1.05 ± 0.3
C20:4n-6 (AA) 14.6 ± 1.4 15.7 ± 1.6 12.6 ± 1.1 12.4 ± 1.3
C20:5n-3 (EPA) 2.05 ± 0.3c 2.19 ± 0.4c 0.75 ± 0.03a,b,d 1.96 ± 0.2c
C22:5n-6 (DPAn-6) 0.16 ± 0.04c 0.19 ± 0.05c 0.05 ± 0.01a,b,d 0.12 ± 0.02c
C22:5n-3 (DPAn-3) 0.78 ± 0.05c 0.86 ± 0.06c,d 0.25 ± 0.01a,b,d 0.70 ± 0.04b,c
C22:6n-3 (DHA) 4.11 ± 0.3c 4.32 ± 0.4c 1.98 ± 0.1a,b,d 3.98 ± 0.3c
Total SFAs 38.8 ± 2.9c 36.5 ± 2.6c,d 49.7 ± 4.4a,b 43.5 ± 3.9b
Total MUFAs 26.4 ± 2.5 27.9 ± 2.4 24.5 ± 2.2 24.8 ± 2.7
Total PUFAs 34.8 ± 3.3c 35.6 ± 3.6c 25.8 ± 2.2a,b 31.7 ± 2.6
Total LCPUFAs 22.9 ± 1.7c 23.7 ± 2.1c 15.8 ± 1.1a,b,d 20.2 ± 1.5c
Total n-6 LCPUFAs 14.9 ± 1.4 16.0 ± 1.6c 12.7 ± 0.9b 12.7 ± 1.4
Total n-3 LCPUFAs 8.00 ± 0.7c 7.70 ± 0.5c 3.10 ± 0.2a,b,d 7.50 ± 0.6c
n-6/n-3 LCPUFA ratio 1.86 ± 0.2c 2.07 ± 0.3c 4.10 ± 0.4a,b,d 1.69 ± 0.3c
  1. Values are expressed as g fatty acid per 100 g FAME and represent the mean ± SEM for n = 12–14 mice per experimental group. Significant differences between the groups are indicated by the letter identifying each group (one-way ANOVA and Newman-Keuls´ post-test; p < 0.05). The identification of saturated and unsaturated fatty acids and their relationships are shown in Table 2