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Table 4 Fatty acid composition of brain phospholipids from control mice and high-fat diet (HFD) fed mice receiving hydroxytyrosol (HT) supplementation

From: Hydroxytyrosol prevents reduction in liver activity of Δ-5 and Δ-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice

  Fatty acid composition (g/100 g FAME)
  Groups
  Control diet (CD) High fat diet (HFD)
  Saline HT Saline HT
Fatty acid (a) (b) (c) (d)
C16:0 35.6 ± 3.1c 34.3 ± 3.3c 47.4 ± 4.6a,b,d 37.3 ± 3.6c
C18:0 5.95 ± 0.6 5.58 ± 0.4 5.15 ± 0.4 5.75 ± 05
C18:1n-9 19.8 ± 1.6 17.9 ± 1.4 20.4 ± 1.7 19.6 ± 1.8
C18:2n-6 (LA) 3.65 ± 0.2 3.52 ± 0.3 3.12 ± 0.2 3.71 ± 0.4
C18:3n-3 (ALA) 1.30 ± 0.3c 1.27 ± 0.2c 0.52 ± 0.05a,b,d 1.11 ± 0.1c
C20:4n-6 (AA) 17.1 ± 1.2c 17.8 ± 1.4c 11.7 ± 0.7a,b,d 15.9 ± 1.6c
C20:5n-3 (EPA) 0.82 ± 0.04c 0.86 ± 0.03c,d 0.51 ± 0.02a,b,d 0.76 ± 0.05c
C22:5n-6 (DPAn-6) 0.30 ± 0.05c,d 0.26 ± 0.05c,d 1.33 ± 0.08a,b,d 1.10 ± 0.04a,b,c
C22:5n-3 (DPAn-3) 0.45 ± 0.04c 0.49 ± 0.05c,d 0.24 ± 0.02a,b,d 0.42 ± 0.03b,d
C22:6n-3 (DHA) 11.5 ± 1.2c 12.3 ± 1.4c 7.02 ± 0.6a,b,d 10.9 ± 1.5c
Total SFAs 42.5 ± 3.1c 40.8 ± 2.9c 52.8 ± 3.8a,b,d 43.8 ± 3.3c
Total MUFAs 21.7 ± 1.9 20.6 ± 1.7 22.5 ± 1.5 21.2 ± 2.0
Total PUFAs 35.8 ± 2.8c 38.6 ± 3.0c 24.7 ± 2.1a,b,d 35.0 ± 3.1c
Total LCPUFAs 30.5 ± 2.3c 32.6 ± 2.9c 21.0 ± 1.8a,b,d 29.5 ± 2.5c
Total n-6 LCPUFAs 17.6 ± 1.3c 18.4 ± 1.4c 13.2 ± 1.0a,b,d 17.3 ± 1.4c
Total n-3 LCPUFAs 12.9 ± 1.0c 14.2 ± 1.1c 7.80 ± 0.4a,b,d 12.2 ± 0.8c
n-6/n-3 LCPUFA ratio 1.36 ± 0.2 1.29 ± 0.2 1.69 ± 0.3 1.41 ± 0.2
  1. Values are expressed as g fatty acid per 100 g FAME and represent the mean ± SEM for n = 12–14 mice per experimental group. Significant differences between the groups are indicated by the letter identifying each group (one-way ANOVA and Newman-Keuls´ post-test; p < 0.05). The identification of saturated and unsaturated fatty acids and their relationships are shown in Table 2