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Table 5 Fatty acid composition of heart phospholipids from control mice and high-fat diet (HFD) fed mice receiving hydroxytyrosol (HT) supplementation

From: Hydroxytyrosol prevents reduction in liver activity of Δ-5 and Δ-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice

  Fatty acid composition (g/100 g FAME)
  Groups
  Control diet (CD) High fat diet (HFD)
  Saline HT Saline HT
Fatty acid (a) (b) (c) (d)
C16:0 33.5 ± 2.9c 32.8 ± 3.0c 42.9 ± 3.4a,b,d 34.7 ± 2.7c
C18:0 4.84 ± 0.3 4.32 ± 0.5 3.94 ± 0.3 5.11 ± 0.5
C18:1n-9 22.8 ± 2.3 23.9 ± 2.5 22.4 ± 1.9 23.3 ± 2.7
C18:2n-6 (LA) 11.7 ± 1.5 11.6 ± 1.3 11.9 ± 1.6 12.5 ± 1.2
C18:3n-3 (ALA) 1.36 ± 0.1c,d 1.44 ± 0.1c,d 0.82 ± 0.04a,b,d 1.12 ± 0.05a,b,c
C20:4n-6 (AA) 11.6 ± 1.4 10.8 ± 1.2 10.90 ± 1.6 11.3 ± 1.7
C20:5n-3 (EPA) 2.82 ± 0.1c,d 2.99 ± 0.1c,d 0.98 ± 0.04a,b,d 1.53 ± 0.05a,b,c
C22:5n-6 (DPAn-6) 0.68 ± 0.1c 0.75 ± 0.05c 0.35 ± 0.02a,b,d 0.62 ± 0.04c
C22:5n-3 (DPAn-3) 0.72 ± 0.05c 0.79 ± 0.1c 0.28 ± 0.01a,b,d 0.67 ± 0.05c
C22:6n-3 (DHA) 5.15 ± 0.3c 5.36 ± 0.2c,d 2.05 ± 0.1a,b,d 4.77 ± 0.2b,c
Total SFAs 39.3 ± 3.3c 37.8 ± 3.0c 47.9 ± 4.1a,b,d 40.3 ± 3.8c
Total MUFAs 25.6 ± 2.6 26.9 ± 2.4 24.4 ± 2.2 25.6 ± 2.7
Total PUFAs 35.1 ± 3.1c 35.3 ± 3.3c 28.0 ± 2.5a,b,d 34.1 ± 3.2c
Total LCPUFAs 21.3 ± 1.8 21.0 ± 1.6 14.8 ± 0.5 19.9 ± 1.7
Total n-6 LCPUFAs 12.4 ± 1.2 11.7 ± 1.1 11.4 ± 0.9 12.4 ± 1.3
Total n-3 LCPUFAs 8.90 ± 0.5c,d 9.30 ± 0.7c,d 3.40 ± 0.2a,b,d 7.50 ± 0.3a,b,c
n-6/n-3 LCPUFA ratio 1.39 ± 0.2c 1.26 ± 0.2c 3.35 ± 0.2a,b,d 1.65 ± 0.3c
  1. Values are expressed as g fatty acid per 100 g FAME and represent the mean ± SEM for n = 12–14 mice per experimental group. Significant differences between the groups are indicated by the letter identifying each group (one-way ANOVA and Newman-Keuls´ post-test; p < 0.05). The identification of saturated and unsaturated fatty acids and their relationships are shown in Table 2