Table 1 Association of laboratory data and LDH, NOm and HDL-C levels in SCA patients

 RBC, x10¹²/L

2.7 (2.4–3.1)

2.5 (2.2–2.7)

2.6 (2.3–2.8)

2.4 (2.2–2.8)

2.5 (2.2–2.8)

2.7 (2.4–3.1)

0.015*

0.176*

0.018

 Hemoglobin, g/dL

7.9 (7.3 –9.1)

7.5 (7.0–8.5)

7.6 (7.20–8.5)

7.5 (6.6–8.5)

7.6 (7.1–8.5)

7.9 (7.1–10.0)

0.040*

0.349

0.049

 Hematocrit, %

23.1 (21.3–26.7)

21.5 (19.8–24.0)

21.7 (20.20–25.5)

21.8 (18.9–24.1)

21.7 (20.0–24.1)

22.9 (20.8–27.7)

0.016*

0.346

0.036

 MCV, fL

83.8 (78.8–88.1)

88.1 (83.5–92.8)

85.1 (81.20–89.8)

88.2 (83.0–94.6)

86.4 (81.6–91.3)

85.0 (80.9–90.5)

0.030

0.120

0.403

 MCH, fL

29.1 (26.5–31.3)

30.5 (28.7–32.6)

29.9 (27.80–32.1)

30.7 (27.8–32.7)

30.4 (28.0–32.7)

29.6 (27.7–31.3)

0.032

0.260

0.288

 Total bilirubin, mg/dL

1.9 (1.3–3.4)

3.1 (1.8–3.9)

2.3 (1.60 –3.8)

3.2 (1.8–3.9)

2.8 (1.8–3.8)

2.0 (0.5–3.8)

0.028

0.183

0.983*

 Direct bilirubin, mg/dL

0.4 (0.3–0.5)

0.5 (0.3–0.6)

0.4 (0.30–0.5)

0.5 (0.4–0.7)

0.5 (0.3–0.6)

0.4 (0.2–0.6)

0.166

0.024

0.501

 Indirect bilirubin, mg/dL

1.5 (0.9–2.6)

2.4 (1.4–3.3)

2.0 (1.20–3.3)

2.4 (1.4–3.3)

2.2 (1.3–3.2)

1.4 (0.4–3.2)

0.025

0.085*

0.958*

 LDH, U/L

1096.0 (837.0–1713.5)

1201.0 (830.0–1931.2)

1096.0 (837.0 –1713.5)

937.5 (650.0–1546.7)

0.152*

0.416*

 Reticulocyte count

5.9 (3.9–8.2)

5.25 (4.40–8.12)

5.0 (3.9–7.1)

7.1 (4.9–8.6)

5.3 (4.2–7.9)

5.9 (4.0–10.7)

0.775*

0.012

0.498*

 Fetal hemoglobin, %

11.4 (4.6–17.4)

8.7 (5.2–13.0)

9.6 (5.3–14.8)

8.9 (3.8–13.0)

7.9 (4.2–13.1)

13.4 (8.7–19.0)

0.077*

0.311*

0.005

 NOm, μM

34.6 (29.1–42.8)

36.1 (27.9–51.0)

37.6 (29.1–51.1)

30.5 (26.3–36.8)

0.702

0.024

 WBC, x 10⁹/L

14.3 (11.5–16.6)

13.7 (11.1–15.8)

13.7 (11.1–16.0)

13.90 (11.7–16.6)

13.9 (11.4–15.9)

12.2 (10.4–16.9)

0.508

0.450

0.751*

 Neutrophil, x 10⁹/L

6664.0 (4209.0–8355.0)

5382.0 (4080.0–7113.5)

5424.0 (3892.0–7182.0)

6088.0 (4485.2–7203.5)

5760.0 (4210.5–71.82.0)

5516.0 (3361.5–7691.0)

0.305

0.387

0.824

 Eosinophil, x 10⁹/L

714.0 (255.5–1967.0)

685.0 (288.7–1608.7)

800.0 (291.0–1807.0)

704.5 (281.5–2109.0)

805.0 (303.5–1925.0)

502.0 (238.5–1328.2)

0.319*

0.336*

0.415*

 Lymphocyte, x 10⁹/L

5408.0 (4540.0–6726.5)

5580.0 (4261.0–7564.5)

5408.0 (3990.0–7224.0)

5939.5 (4491.5–7569.7)

5560.0 (4359.0–7209.5)

5798.0 (3751.5–7728.0)

0.508

0.439*

0.647

 Monocyte, x 10⁹/L

290.0 (169.0–419.0)

454.5 (248.5–763.2)

338.0 (222.0–576.0)

377.5 (212.5–863.0)

330.0 (212.0–680.5)

492.0 (309.0–720.7)

0.017*

0.296*

0.792

 Platelet, x10³/mL

450.0 (350.0–514.0)

439.0 (367.7–550.2)

445.0 (384.0–558.0)

419.5 (342.5–514.5)

442.0 (358.0–559.0)

439.5 (402.0–497.0)

0.982

0.337

0.345

 Total Cholesterol, mg/dL

132.0 (85.0–152.0)

120.5 (101.5–144.5)

131.0 (111.0–153.0)

109.0 (85.5–146.0)

0.933

0.014*

 HDL-C, mg/dL

33.0 (28.5–40.5)

31.0 (26.0–36.2)

34.0 (28.0–40.0)

30.0 (26.0–33.2)

0.108

0.018

 LDL-C, mg/dL

66.0 (41.5–87.5)

67.0 (44.0–88.2)

74.0 (57.0–99.0)

51.5 (30.5–84.2)

66.0 (40.0–84.0)

92.0 (73.5–128.2)

0.982

0.007*

<0.001

 VLDL-C, mg/dL

22.0 (16.0–33.0)

22.0 (17.0–31.0)

21.0 (16.0–26.0)

28.0 (18.0–35.0)

23.0 (17.0–32.0)

20.0 (15.5–28.5)

0.948

0.003*

0.036

 Triglycerides, mg/dL

109.0 (81.0–164.0)

110.0 (84.0–155.2)

103.0 (78.0–130.0)

139.0 (91.7–176.5)

113.0 (83.5–158.5)

101.5 (78.7–144.0)

0.951

0.008*

0.441