A Single Nucleotide Polymorphism in the FADS1 Gene is Associated with Plasma Fatty Acid and Lipid Profiles and Might Explain Gender Difference in Body Fat Distribution

Table 3 The association between rs174547 and plasma fatty acids (N = 67)

Fatty acid	Effect (SD)	P value^a			Effect (SD)	P value^b
Fatty acid	Effect (SD)	Addictive	Dominant	Recessive	Effect (SD)	Addictive	Dominant	Recessive
Palmitic acid (16:0)	−0.98 (1.09)	0.775	0.904	0.371	−1.13 (1.14)	0.743	0.914	0.324
Stearic acid (18:0)	−0.60 (0.96)	0.865	0.589	0.536	0.32 (0.53)	0.767	0.548	0.650
Palmitoleic acid (16:1)	0.10 (0.06)	0.277	0.591	0.127	0.06 (0.06)	0.476	0.711	0.333
Oleic acid (18:1)	0.40 (0.20)	0.049*	0.057	0.318	0.47 (0.25)	0.074	0.063	0.525
Linoleic acid (18:2)	2.85 (1.42)	0.053	0.181	0.049*	3.62 (1.44)	0.022*	0.128	0.015*
Dihomo-γ-linolenic acid (20:3)	−0.18 (0.25)	0.982	0.727	0.476	−0.37 (0.23)	0.523	0.979	0.116
Arachidonic acid (20:4)	−1.90 (0.41)	<.0001***	<.0001***	0.18	−1.99 (0.41)	<.0001***	<.0001***	0.171
Α-linolenic acid (18:3)	0.17 (0.15)	0.448	0.255	0.711	0.22 (0.15)	0.219	0.147	0.902
Eicosapentaenoic acid (20:5)	−0.26 (0.19)	0.177	0.21	0.438	−0.31 (0.19)	0.114	0.194	0.222
Docosahexaenoic acid (22:6)	−0.1 (0.05)	0.124	0.367	0.06	−0.13 (0.05)	0.04*	0.192	0.020*
Δ6 desaturase	−1.35 (0.38)	0.004**	0.001**	0.723	−1.34 (0.37)	0.005**	0.001**	0.982
Δ5 desaturase	−0.003 (0.008)	0.383	0.696	0.194	−0.03 (0.01)	0.083	0.374	0.017*

^aAdjusted for age and sex; ^bAdjusted for age, sex, smoke, drinking, and BMI; *P < 0.05, **P < 0.01, ***P < 0.0001

ISSN: 1476-511X