A Single Nucleotide Polymorphism in the FADS1 Gene is Associated with Plasma Fatty Acid and Lipid Profiles and Might Explain Gender Difference in Body Fat Distribution

Guo, Huilan; Zhang, Lichao; Zhu, Chaonan; Yang, Fei; Wang, Shanshan; Zhu, Shankuan; Ma, Xiaoguang

doi:10.1186/s12944-017-0459-9

Lipids in Health and Disease

Table 5 The association between rs174547 and fat distribution in women (N = 586)

From: A Single Nucleotide Polymorphism in the FADS1 Gene is Associated with Plasma Fatty Acid and Lipid Profiles and Might Explain Gender Difference in Body Fat Distribution

Indicators	T/T	T/C	C/C		P value^a		Effect (SD)	P value^b			Effect (SD)	P value^c
Indicators	Mean (SD)	Mean (SD)	Mean (SD)	Addictive	Dominant	Recessive	Effect (SD)	Addictive	Dominant	Recessive	Effect (SD)	Addictive	Dominant	Recessive
BMI (kg/m²)	23.60 (3.28)	23.66 (3.06)	22.64 (3.30)	0.026	0.274	0.006**	-	-	-	-	-	-	-	-
Weight (kg)	57.72 (8.75)	58.11 (8.15)	55.11 (8.59)	0.029*	0.424	0.002**	−0.46 (0.42)	0.733	0.71	0.281	-	-	-	-
Waist circumference (cm)	80.54 (9.08)	80.74 (8.45)	77.71 (9.36)	0.017*	0.235	0.003**	−0.47 (0.43)	0.337	0.585	0.271	-	-	-	-
Hip circumference (cm)	92.02 (6.00)	91.89 (5.35)	90.88 (5.94)	0.129	0.327	0.111	0.37 (0.34)	0.63	0.859	0.27	-	-	-	-
Waist-to-height ratio	0.52 (0.06)	0.52 (0.06)	0.50 (0.06)	0.023*	0.181	0.011*	−0.002 (0.002)	0.402	0.367	0.656	-	-	-	-
Waist-to-hip ratio	0.87 (0.06)	0.88 (0.06)	0.85 (0.07)	0.018*	0.357	0.001**	−0.01 (0.01)	0.184	0.696	0.049*	-	-	-	-
Android fat mass percent	3.18 (0.80)	3.12 (0.79)	2.89 (0.87)	0.002**	0.023*	0.005**	−0.09 (0.04)	0.052	0.039*	0.286	−0.09 (0.04)	0.052	0.041*	0.278
Gynoid fat mass percent	5.64 (0.90)	5.59 (0.85)	5.54 (0.97)	0.291	0.442	0.315	−0.02 (0.07)	0.922	0.766	0.856	0.02 (0.08)	0.948	0.900	0.786
Android/gynoid fat ratio	0.57 (0.16)	0.57 (0.16)	0.53 (0.18)	0.038*	0.103	0.068	−0.01 (0.01)	0.231	0.206	0.505	-	-	-	-
Total fat mass percent	32.17 (5.83)	31.94 (5.73)	30.07 (6.48)	0.006**	0.08	0.003**	−0.32 (0.20)	0.118	0.169	0.230	-	-	-	-
Limb fat mass percent	12.80 (2.41)	12.66 (2.39)	12.19 (2.39)	0.040*	0.165	0.037*	−0.10 (0.11)	0.364	0.374	0.557	−0.11 (0.17)	0.522	0.499	0.724
Trunk fat mass percent	18.12 (4.09)	18.05 (4.08)	16.66 (4.65)	0.006**	0.101	0.003**	−0.21 (0.14)	0.14	0.235	0.206	−0.18 (0.14)	0.185	0.299	0.240

^aAdujsted for age; ^bAdjusted for age, income, smoking, drinking, physical activity and BMI; ^cAdjusted for age, income, smoking, drinking, physical activity, BMI, and other regional fat (For android fat mass percent, the gynoid fat mass percent was further adjusted, vice versa; for limb fat mass percent, the trunk fat mass percent was further adjusted, vice versa); *P < 0.05, **P < 0.01

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ISSN: 1476-511X

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