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Table 3 Physicochemical characteristics of Meclizine HCl ER matrix pellets formulations

From: Lipids bearing extruded-spheronized pellets for extended release of poorly soluble antiemetic agent—Meclizine HCl

Formulation Code

Angle of Repose

Bulk Density

Tapped Density

Compressibility Index

Hausner Ratio

Moisture Content

Yield

Friability

Assay

θ

g/ml

g/ml

%

%

%

%

%

F1

21.324

0.666

0.714

6.723

1.072

18.591

88.641

0.523

96.163

F2

21.697

0.689

0.741

6.992

1.075

15.143

84.971

0.608

99.741

F3

20.582

0.652

0.704

7.386

1.080

9.947

74.698

0.589

97.957

F4

25.639

0.747

0.807

7.435

1.080

25.667

79.614

0.399

96.745

F5

24.714

0.752

0.821

8.404

1.092

31.357

74.018

0.408

98.237

F6

25.916

0.789

0.859

8.149

1.089

35.987

69.943

0.418

100.024

F7

25.146

0.799

0.876

8.790

1.096

21.228

85.472

0.476

99.242

F8

26.357

0.765

0.832

8.053

1.088

18.298

84.608

0.287

97.589

F9

28.699

0.760

0.834

8.873

1.097

13.952

90.947

0.591

98.241

F10

37.473

0.839

0.999

16.016

1.191

13.694

88.364

0.340

99.415

F11

38.258

0.801

0.989

19.009

1.235

11.037

91.348

0.379

99.876

F12

40.981

0.779

0.975

20.103

1.252

9.024

94.289

0.251

98.279

F13

25.007

0.671

0.710

5.493

1.058

29.195

76.617

0.308

99.873

F14

27.242

0.606

0.648

6.481

1.069

24.834

81.753

0.291

100.390

F15

26.321

0.669

0.719

6.954

1.075

19.479

85.439

0.258

99.220

F16

25.364

0.769

0.831

7.461

1.081

5.870

92.760

0.578

97.289

F17

26.821

0.785

0.861

8.827

1.097

3.930

96.219

0.530

99.657

F18

28.974

0.815

0.906

10.044

1.112

2.966

97.124

0.599

98.917

F19

32.147

0.826

0.931

11.278

1.127

5.942

94.283

0.276

99.814

F20

34.917

0.839

0.964

12.967

1.149

2.456

97.068

0.342

97.668

F21

25.231

0.654

0.713

8.275

1.090

27.894

87.925

0.562

98.749

F22

27.951

0.678

0.730

7.123

1.077

24.276

91.478

0.431

98.529

F23

28.367

0.651

0.710

8.310

1.091

19.875

83.879

0.539

99.384

F24

34.852

0.775

0.891

13.019

1.150

21.763

86.168

0.487

99.876

F25

32.753

0.801

0.939

14.696

1.172

18.258

87.309

0.509

98.254

F26

34.258

0.794

0.939

15.442

1.183

15.734

90.951

0.417

97.413

F27

31.159

0.701

0.798

12.155

1.138

26.013

79.571

0.378

99.643

F28

31.984

0.755

0.879

14.107

1.164

9.876

96.527

0.314

98.872

F29

32.679

0.721

0.848

14.976

1.176

10.325

94.994

0.291

100.954

F30

32.774

0.745

0.852

12.559

1.144

7.410

90.890

0.451

98.371

F31

33.891

0.762

0.885

13.898

1.161

4.337

95.840

0.514

100.547

F32

33.694

0.800

0.937

14.621

1.171

4.230

88.197

0.479

99.875