Lipids bearing extruded-spheronized pellets for extended release of poorly soluble antiemetic agent—Meclizine HCl

Qazi, Faaiza; Shoaib, Muhammad Harris; Yousuf, Rabia Ismail; Nasiri, Muhammad Iqbal; Ahmed, Kamran; Ahmad, Mansoor

doi:10.1186/s12944-017-0466-x

Lipids in Health and Disease

Table 4 Kinetic parameters for dissolution data of different Meclizine HCl ER matrix pellets formulations according to various kinetic models

From: Lipids bearing extruded-spheronized pellets for extended release of poorly soluble antiemetic agent—Meclizine HCl

Codes	Zero order		First order		Higuchi model		Hixson-Crowell model		Baker and Lonsdale model		Jander’s equation model		Korsmeyer-Peppas model			MDT	DE₆
Codes	R2	K0 (h-1)	R2	K1 (h-1)	R2	KH (h-1/2)	R2	KHC (h-1)	R2	KBL (h-1)	R2	KJ (h-1/2)	R2	KKP (h-n)	n	h	%
F1	0.917	16.152	0.937	1.992	0.972	45.274	0.977	1.142	0.974	0.197	0.925	0.504	0.986	0.507	0.490	1.724	N/A
F2	0.964	18.114	0.954	0.225	0.990	45.081	0.995	1.012	0.993	0.165	0.966	0.771	0.993	0.620	0.425	0.819	N/A
F3	0.987	29.600	0.961	3.243	1.000	64.028	0.988	1.756	0.983	0.256	0.961	1.028	1.000	0.724	0.451	0.687	N/A
F8	0.998	25.444	0.954	2.204	0.983	54.270	0.973	1.353	0.966	0.250	0.935	0.840	0.972	0.701	0.536	0.531	N/A
F9	0.991	12.015	0.809	1.515	0.973	40.471	0.921	0.461	0.866	0.116	0.830	0.608	0.985	0.323	0.575	1.343	N/A
F11	0.997	21.762	0.961	2.611	0.992	53.325	0.983	0.665	0.948	0.205	0.948	0.600	0.997	0.528	0.572	1.496	N/A
F12	0.992	5.237	0.981	0.136	0.982	22.473	0.991	0.124	0.939	0.016	0.944	0.222	0.991	0.185	0.556	4.884	29.676
F14	0.958	20.305	0.986	2.029	0.979	44.307	1.000	1.355	1.000	0.205	0.988	0.623	0.995	0.809	0.281	0.528	N/A
F15	0.988	17.162	0.852	1.342	0.980	41.982	0.921	0.948	0.911	0.139	0.861	0.485	0.978	0.692	0.323	0.921	N/A
F16	0.957	15.413	0.908	2.089	0.989	42.662	0.978	0.760	0.973	0.155	0.936	0.686	0.990	0.481	0.519	1.159	NA
F17	0.978	7.315	0.916	0.515	0.989	31.730	0.977	0.230	0.924	0.066	0.914	0.503	0.993	0.244	0.551	4.836	33.933
F18	0.974	7.697	0.957	0.404	0.979	33.287	0.989	0.235	0.947	0.041	0.930	0.416	0.978	0.215	0.597	4.832	33.698
F19	0.995	30.747	0.954	2.650	1.000	66.247	0.982	1.786	0.975	0.259	0.950	0.813	0.999	0.719	0.461	0.700	NA
F20	0.995	5.366	0.968	0.150	0.956	22.691	0.982	0.120	0.905	0.014	0.913	0.204	0.978	0.166	0.578	5.448	27.074
F22	0.887	17.594	0.663	3.561	0.841	46.653	0.740	0.748	0.682	0.356	0.654	1.950	0.905	0.472	0.533	1.921	NA
F23	0.967	14.414	0.796	2.389	0.966	42.713	0.907	0.606	0.872	0.195	0.832	1.206	0.963	2.389	0.501	1.855	NA
F24	0.990	24.496	0.966	2.309	1.000	52.932	0.990	1.546	0.987	0.230	0.963	0.706	1.000	0.777	0.345	0.604	NA
F25	0.960	14.995	0.874	1.205	0.971	37.046	0.933	0.858	0.929	0.128	0.886	0.442	0.973	0.723	0.273	0.816	NA
F26	0.950	13.089	0.908	0.635	0.987	36.336	0.978	0.701	0.979	0.103	0.940	0.315	0.992	0.637	0.316	1.023	NA
F27	0.875	16.587	0.966	2.049	0.937	42.169	0.988	0.962	0.993	0.115	0.985	0.377	0.953	0.559	0.517	0.728	NA
F28	0.991	7.284	0.842	0.937	0.959	30.910	0.927	0.201	0.802	0.109	0.839	0.310	0.984	0.166	0.696	6.008	26.679
F29	0.991	5.791	0.985	0.148	0.988	24.933	0.995	0.143	0.948	0.022	0.950	0.207	0.997	0.146	0.675	4.835	31.384
F30	1.000	36.837	1.000	5.368	1.000	62.856	1.000	3.197	1.000	0.479	1.000	1.176	1.000	0.987	0.298	0.343	N/A
F31	0.959	15.883	0.964	1.980	0.982	39.478	0.994	0.960	0.993	0.153	0.967	0.678	0.982	0.645	0.389	0.743	N/A
F32	0.965	9.731	0.820	2.149	0.993	31.476	0.938	0.448	0.929	0.163	0.880	0.539	0.995	0.508	0.371	1.724	N/A

“R2 “is the regression coefficient; “K” is the release rate constant for respective models; “n” is the diffusion exponent; “MDT” is the mean dissolution time, “DE” is the dissolution efficiency at 6 h. N/A indicates that DE is not calculated as 90% drug released before 6 h. F4, F5, F6, F7, F10, F13 and F21 released 90% drug within 2 h

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