|
Biomarkers
|
FH
|
RUC
|
NC
|
p-value
|
|---|
|
n (%)
|
n (%)
|
n (%)
|
|---|
|
hsCRP (mg/L)
|
|
< 0.30
|
19 (18.3)
|
3 (7.5)
|
22 (15.3)
|
0.017
|
|
0.30–0.69
|
15 (14.4)
|
5 (12.5)
|
39 (27.1)
|
|
0.70–1.49
|
25 (24.0)
|
11 (27.5)
|
42 (29.2)
|
|
≥ 1.5
|
45 (43.3)
|
21 (52.5)
|
41 (28.5)
|
|
sICAM-1 (ng/ml)
|
|
< 472
|
54 (45.8)
|
3 (8.3)
|
20 (13.0)
|
<0.001
|
|
472–603
|
6 (5.1)
|
4 (11.1)
|
48 (31.2)
|
|
604–772
|
7 (5.9)
|
6 (16.6)
|
50 (32.5)
|
|
≥ 773
|
51 (43.2)
|
23 (63.9)
|
36 (23.3)
|
|
E-selectin (ng/mL)
|
|
< 16.53
|
8 (6.5)
|
50 (100)
|
65 (36.9)
|
<0.001
|
|
16.5–26.0
|
8 (6.5)
|
0
|
54 (30.2)
|
|
26.1–101.7
|
29 (23.6)
|
0
|
59 (33.0)
|
|
≥ 101.8
|
78 (63.4)
|
0
|
0
|
|
ox-LDL (mU/L)
|
|
< 23.9
|
27 (24.1)
|
38 (59.4)
|
71 (39.0)
|
<0.001
|
|
23.9–35.4
|
8 (7.1)
|
5 (7.8)
|
62 (34.1)
|
|
35.5–53.7
|
26 (23.2)
|
15 (23.4)
|
43 (23.6)
|
|
≥ 53.8
|
51 (45.5)
|
6 (9.4)
|
6 (3.3)
|
|
MDA (nmol/mL)
|
|
< 1.02
|
19 (22.1)
|
6 (12.5)
|
43 (27.4)
|
<0.001
|
|
1.02–1.37
|
2 (2.3)
|
5 (10.4)
|
71 (45.2)
|
|
1.38–2.33
|
11 (12.8)
|
24 (50.0)
|
43 (27.4)
|
|
≥ 2.34
|
54 (62.8)
|
13 (27.1)
|
0 (0.0)
|
|
F2- Isoprostanes (pg/L)
|
|
< 1.04
|
0 (0.0)
| |
64 (42.1)
|
<0.001
|
|
1.04–3.48
|
0 (0.0)
| |
47 (30.9)
|
|
3.49–308
|
11 (21.6)
| |
41 (27.0)
|
|
≥ 309
|
40 (78.4)
| |
0 (0.0)
|
-
FH familial hypercholesterolaemia, RUC related unaffected controls, NC normolipaemic subjects, hsCRP high sensitivity C-reactive protein, sICAM-1 soluble intercellular adhesion molecule-1, MDA Malondialdehyde
- Italic p value < 0.05 consideredsignificant
