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Table 2 Association between groups with quartiles of biomarkers of inflammation, endothelial activation and oxidative stress

From: Enhanced status of inflammation and endothelial activation in subjects with familial hypercholesterolaemia and their related unaffected family members: a case control study

Biomarkers FH RUC NC p-value
n (%) n (%) n (%)
hsCRP (mg/L)
  < 0.30 19 (18.3) 3 (7.5) 22 (15.3) 0.017
 0.30–0.69 15 (14.4) 5 (12.5) 39 (27.1)
 0.70–1.49 25 (24.0) 11 (27.5) 42 (29.2)
  ≥ 1.5 45 (43.3) 21 (52.5) 41 (28.5)
sICAM-1 (ng/ml)
  < 472 54 (45.8) 3 (8.3) 20 (13.0) <0.001
 472–603 6 (5.1) 4 (11.1) 48 (31.2)
 604–772 7 (5.9) 6 (16.6) 50 (32.5)
  ≥ 773 51 (43.2) 23 (63.9) 36 (23.3)
E-selectin (ng/mL)
  < 16.53 8 (6.5) 50 (100) 65 (36.9) <0.001
 16.5–26.0 8 (6.5) 0 54 (30.2)
 26.1–101.7 29 (23.6) 0 59 (33.0)
  ≥ 101.8 78 (63.4) 0 0
ox-LDL (mU/L)
  < 23.9 27 (24.1) 38 (59.4) 71 (39.0) <0.001
 23.9–35.4 8 (7.1) 5 (7.8) 62 (34.1)
 35.5–53.7 26 (23.2) 15 (23.4) 43 (23.6)
  ≥ 53.8 51 (45.5) 6 (9.4) 6 (3.3)
MDA (nmol/mL)
  < 1.02 19 (22.1) 6 (12.5) 43 (27.4) <0.001
 1.02–1.37 2 (2.3) 5 (10.4) 71 (45.2)
 1.38–2.33 11 (12.8) 24 (50.0) 43 (27.4)
  ≥ 2.34 54 (62.8) 13 (27.1) 0 (0.0)
F2- Isoprostanes (pg/L)
  < 1.04 0 (0.0)   64 (42.1) <0.001
 1.04–3.48 0 (0.0)   47 (30.9)
 3.49–308 11 (21.6)   41 (27.0)
  ≥ 309 40 (78.4)   0 (0.0)
  1. FH familial hypercholesterolaemia, RUC related unaffected controls, NC normolipaemic subjects, hsCRP high sensitivity C-reactive protein, sICAM-1 soluble intercellular adhesion molecule-1, MDA Malondialdehyde
  2. Italic p value < 0.05 consideredsignificant