Table 1 Basic characteristics of PLIN proteins
From: Perilipins: a diversity of intracellular lipid droplet proteins
Proteins | Alternative names | Major cite of expression | Other cites of expression | Function |
|---|---|---|---|---|
PLIN1 | Perilipin A | WAT | BAT, cardiac muscle liposarcoma | hormone-induced lipolysis large LD stabilization |
PLIN2 | ADRP, ADFP (human ADRP) Adipophilin | Liver | premature adipocytes macrophages sebocytes mammary gland epithelia choriocaricinoma cells (BeWo) ubiquitously expressed | adipocyte differentiation small LD generation LD stabilization |
PLIN3 | TIP47 | ubiquitous | skeletal muscle neutrophils, mast cells retinal pigment epithelium sebocytes | LD stabilization (compensation of PLIN2) PGE2 production intracellular trafficking |
PLIN4 | S3–12 | WAT | hMSC (induced during differentiation) skeletal muscle | human adipocyte differentiation |
PLIN5 | MLDP, OXPAT, LSDP5 | cardiac muscle BAT skeletal muscle | islet β-cells hepatic stellate cells | LD stabilization FA supply to mitochondria |