VDR Gene variation and insulin resistance related diseases

Han, Fei-fei; Lv, Ya-li; Gong, Li-li; Liu, He; Wan, Zi-rui; Liu, Li-hong

doi:10.1186/s12944-017-0477-7

Lipids in Health and Disease

Table 5 Summary of meta-analysis

From: VDR Gene variation and insulin resistance related diseases

Comparison of outcome	No. of trials	No. of Case	No. of Control	Effect size (95% confidence intervals)	P	Test for heterogeneity
Comparison of outcome	No. of trials	No. of Case	No. of Control	Effect size (95% confidence intervals)	P	I ² (%)	P
ApaI
GG/GT + TT	14	3212	3360	1.08 [0.91, 1.28]	0.37	30	0.14
T2DM	9	2017	2555	1.00 [0.78, 1.28]	1	51	0.05
PCOS	5	1195	805	1.15 [0.88, 1.50]	0.31	0	0.47
GG + GT/TT	14	3212	3360	1.04 [0.89, 1.21]	0.62	38	0.08
T2DM	9	2017	2555	0.93 [0.79, 1.11]	0.44	17	0.29
PCOS	5	1195	805	1.15 [0.90, 1.45]	0.27	30	0.22
G allele	14	3212	3360	1.04 [0.95, 1.14]	0.36	26	0.18
T2DM	9	2017	2555	0.97 [0.85, 1.11]	0.7	42	0.1
PCOS	5	1195	805	1.11 [0.96, 1.27]	0.15	0	0.84
T allele	14	3212	3360	1.02 [0.91, 1.15]	0.7	56	0.0005
T2DM	9	2017	2555	1.03 [0.90, 1.18]	0.68	43	0.09
PCOS	5	1195	805	1.07 [0.83, 1.37]	0.62	70	0.01
Ethic
GG/GT + TT	13	3087	3235	1.09 [0.91, 1.30]	0.34	34	0.11
Caucasian	5	1488	1929	1.20 [0.99, 1.45]	0.06	0	0.41
Caucasian (dark)	6	1091	1090	0.94 [0.64, 1.36]	0.73	52	0.07
Asian	2	508	216	1.24 [0.88, 1.76]	0.22	0	0.88
GG + GT/TT	13	3087	3235	1.08 [0.94, 1.24]	0.29	21	0.23
Caucasian	5	1488	1929	1.13 [0.87, 1.46]	0.36	49	0.1
Caucasian (dark)	6	1091	1090	0.97 [0.81, 1.15]	0.7	0	0.89
Asian	2	508	216	1.62 [1.03, 2.53]	0.04	0	0.35
G allele	13	3087	3235	1.06 [0.98, 1.16]	0.16	13	0.31
Caucasian	5	1488	1929	1.11 [0.98, 1.27]	0.06	0	0.51
Caucasian (dark)	6	1091	1090	0.96 [0.85, 1.09]	0.51	0	0.66
Asian	2	508	216	1.25 [0.99, 1.57]	0.1	17	0.3
T allele	13	3087	3235	1.01 [0.89, 1.14]	0.93	56	0.008
Caucasian	5	1488	1929	0.94 [0.80, 1.09]	0.4	42	0.14
Caucasian (dark)	6	1091	1090	1.16 [0.97, 1.38]	0.1	47	0.009
Asian	2	508	216	0.80 [0.64, 1.01]	0.06	0	0.51
Latitude
GG/GT + TT	14	3212	3360	1.08 [0.91, 1.28]	0.37	30	0.14
Low (<30)	5	1136	834	0.86 [0.65, 1.14]	0.3	19	0.29
Middle (30–60)	9	2076	2526	1.22 [1.04, 1.43]	0.02	0	0.43
GG + GT/TT	14	3212	3360	1.04 [0.89, 1.21]	0.62	38	0.08
Low (<30)	5	1136	834	0.91 [0.73, 1.15]	0.44	17	0.31
Middle (30–60)	9	2076	2526	1.12 [0.92, 1.36]	0.27	42	0.08
G allele	14	3212	3360	1.04 [0.95, 1.14]	0.36	26	0.18
Low (<30)	5	1136	834	0.92 [0.80, 1.07]	0.27	10	0.35
Middle (30–60)	9	2076	2526	1.12 [1.01, 1.23]	0.02	0	0.44
T allele	14	3212	3360	1.02 [0.91, 1.15]	0.7	56	0.005
Low (<30)	5	1136	834	1.09 [0.94, 1.25]	0.26	10	0.35
Middle (30–60)	9	2076	2526	0.99 [0.84, 1.18]	0.95	66	0.003
BsmI
AA/GA + GG	22	4294	4157	0.95 [0.78, 1.16]	0.64	41	0.02
T2DM	14	2802	3051	0.99 [0.75, 1.31]	0.93	55	0.007
PCOS	4	835	443	1.11 [0.77, 1.58]	0.58	0	0.61
MetS	4	657	663	0.72 [0.50, 1.05]	0.09	0	0.5
AA + GA/GG	22	4294	4157	1.06 [0.86, 1.31]	0.59	69	<0.00001
T2DM	14	2802	3051	1.19 [0.90, 1.57]	0.21	71	<0.001
PCOS	4	835	443	1.06 [0.79, 1.42]	0.7	19	0.29
MetS	4	657	663	0.62 [0.45, 0.86]	0.005	11	0.34
A allele	22	4294	4157	0.97 [0.83, 1.13]	0.67	72	<0.00001
T2DM	14	2802	3051	1.05 [0.85, 1.28]	0.67	76	<0.00001
PCOS	4	835	443	0.96 [0.79, 1.16]	0.65	12	0.33
MetS	4	657	663	0.71 [0.54, 0.93]	0.01	37	0.19
G allele	22	4294	4157	1.08 [0.89, 1.32]	0.42	83	<0.00001
T2DM	14	2802	3051	0.96 [0.78, 1.17]	0.67	76	<0.00001
PCOS	4	835	443	1.27 [0.67, 2.40]	0.73	91	0.00001
MetS	4	657	663	1.41 [1.07, 1.85]	0.01	37	0.19
Ethic
AA/GA + GG	21	4194	4057	0.98 [0.80, 1.21]	0.87	40	0.03
Caucasian	7	1683	2121	1.01 [0.81, 1.26]	0.92	9	0.36
Caucasian (dark)	7	913	793	1.05 [0.82, 1.35]	0.69	0	0.82
Asian	7	1598	1143	0.90 [0.39, 2.08]	0.81	67	0.006
AA + GA/GG	21	4194	4057	1.10 [0.89, 1.36]	0.38	68	<0.00001
Caucasian	7	1683	2121	0.98 [0.82, 1.18]	0.84	25	0.24
Caucasian (dark)	7	913	793	1.50 [1.16, 1.93]	0.002	19	0.29
Asian	7	1598	1143	0.89 [0.49, 1.61]	0.69	80	<0.00001
A allele	21	4194	4057	1.02 [0.87, 1.19]	0.84	72	<0.00001
Caucasian	7	1683	2121	1.03 [0.86, 1.23]	0.75	59	0.02
Caucasian (dark)	7	913	793	1.23 [1.07, 1.42]	0.004	0	0.91
Asian	7	1598	1143	0.81 [0.49, 1.34]	0.42	86	<0.00001
G allele	21	4194	4057	1.06 [0.87, 1.29]	0.57	83	<0.00001
Caucasian	7	1683	2121	1.19 [0.85, 1.65]	0.32	89	<0.00001
Caucasian (dark)	7	913	793	0.81 [0.70, 0.94]	0.004	0	0.91
Asian	7	1598	1143	1.23 [0.74, 2.04]	0.42	86	<0.00001
Latitude
AA/GA + GG	22	4294	4157	0.95 [0.78, 1.16]	0.64	41	0.02
Low (<30)	5	912	659	0.74 [0.52, 1.05]	0.09	39	0.16
Middle (30–60)	17	3382	3498	1.05 [0.83, 1.33]	0.68	37	0.06
AA + GA/GG	22	4294	4157	1.06 [0.86, 1.31]	0.59	69	<0.00001
Low (<30)	5	912	659	1.32 [0.73, 2.38]	0.35	70	0.009
Middle (30–60)	17	3382	3498	1.00 [0.81, 1.23]	0.97	61	0.0005
A allele	22	4294	4157	0.97 [0.83, 1.13]	0.67	72	<0.00001
Low (<30)	5	912	659	0.96 [0.64, 1.43]	0.83	80	0.0005
Middle (30–60)	17	3382	3498	0.97 [0.82, 1.15]	0.7	70	<0.00001
Gallele	22	4294	4157	1.08 [0.89, 1.32]	0.42	83	<0.00001
Low (<30)	5	912	659	1.04 [0.70, 1.56]	0.83	80	0.0005
Middle (30–60)	17	3382	3498	1.09 [0.87, 1.37]	0.44	84	<0.00001
TaqI
TT/TC + CC	19	3533	4024	1.00 [0.82, 1.21]	0.96	60	0.004
T2DM	13	2305	3187	1.09 [0.84, 1.42]	0.51	60	0.003
PCOS	6	1228	837	0.86 [0.62, 1.20]	0.37	65	0.01
TT + TC/CC	19	3533	4024	0.88 [0.73, 1.06]	0.17	43	0.02
T2DM	13	2305	3187	0.92 [0.74, 1.14]	0.43	41	0.06
PCOS	6	1228	837	0.77 [0.51, 1.16]	0.22	52	0.06
T allele	19	3533	4024	0.89 [0.75, 1.06]	0.18	79	<0.0001
T2DM	13	2305	3187	1.01 [0.86, 1.18]	0.95	60	0.003
PCOS	6	1228	837	0.68 [0.48, 0.96]	0.03	84	<0.0001
C allele	19	3533	4024	1.13 [0.95, 1.34]	0.18	79	<0.0001
T2DM	13	2305	3187	0.99 [0.85, 1.17]	0.95	60	0.03
PCOS	6	1228	837	1.47 [1.03, 2.09]	0.03	84	0.00001
Ethic
TT/TC + CC	17	3368	3859	0.93 [0.78, 1.12]	0.45	49	0.01
Caucasian	7	1653	2190	1.10 [0.90, 1.36]	0.35	38	0.14
Caucasian (dark)	7	1159	1121	0.75 [0.58, 0.97]	0.03	46	0.08
Asian	3	556	548	1.94 [0.32, 11.77]	0.47	0	0.44
TT + TC/CC	17	3368	3859	0.88 [0.72, 1.07]	0.2	48	0.01
Caucasian	7	1653	2190	1.12 [0.82, 1.53]	0.47	50	0.06
Caucasian (dark)	7	1159	1121	0.76 [0.57, 1.02]	0.07	39	0.13
Asian	3	556	548	0.67 [0.47, 0.96]	0.03	0	0.4
T allele	17	3368	3859	0.84 [0.71, 1.01]	0.06	78	<0.00001
Caucasian	7	1653	2190	0.94 [0.66, 1.33]	0.73	90	<0.00001
Caucasian (dark)	7	1159	1121	0.80 [0.68, 0.95]	0.01	41	0.12
Asian	3	556	548	0.73 [0.51, 1.04]	0.08	10	0.33
C allele	17	3368	3859	1.18 [0.99, 1.41]	0.06	78	<0.00001
Caucasian	7	1653	2190	1.06 [0.75, 1.51]	0.73	90	<0.00001
Caucasian (dark)	7	1159	1121	1.24 [1.05, 1.47]	0.01	42	0.11
Asian	3	556	548	1.37 [0.96, 1.94]	0.08	10	0.33
Latitude
TT/TC + CC	18	3493	3984	0.95 [0.80, 1.12]	0.52	47	0.02
Low (<30)	5	934	896	0.86 [0.67, 1.09]	0.2	24	0.26
Middle (30–60)	13	2559	3088	1.00 [0.79, 1.25]	0.97	52	0.01
TT + TC/CC	18	3493	3984	0.87 [0.72, 1.05]	0.15	45	0.02
Low (<30)	5	934	896	0.88 [0.70, 1.12]	0.3	0	0.44
Middle (30–60)	13	2559	3088	0.87 [0.67, 1.13]	0.29	56	0.007
T allele	18	3493	3984	0.85 [0.72, 1.01]	0.06	77	<0.00001
Low (<30)	5	934	896	0.90 [0.78, 1.02]	0.11	0	0.69
Middle (30–60)	13	2559	3088	0.84 [0.66, 1.07]	0.15	83	<0.00001
C allele	18	3493	3984	1.17 [0.99, 1.39]	0.06	77	<0.00001
Low (<30)	5	934	896	1.11 [0.97, 1.27]	0.12	0	0.68
Middle (30–60)	13	2559	3088	1.19 [0.94, 1.51]	0.15	83	<0.00001
FokI
CC/CT + TT	18	4992	6230	1.03 [0.82, 1.30]	0.79	80	<0.00001
T2DM	9	1086	690	1.10 [0.75, 1.60]	0.63	81	<0.00001
PCOS	5	631	559	1.20 [0.97, 1.48]	0.1	0	0.49
MetS	3	1084	1960	0.60 [0.16, 2.33]	0.46	93	<0.00001
CC + CT/TT	18	4992	6230	0.92 [0.72, 1.17]	0.49	74	<0.00001
T2DM	9	1086	690	1.02 [0.76, 1.37]	0.88	58	0.01
PCOS	5	631	559	1.29 [0.82, 2.03]	0.27	41	0.15
MetS	3	1084	1960	0.35 [0.10, 1.19]	0.09	93	<0.00001
C allele	18	4992	6230	0.99 [0.87, 1.12]	0.84	73	<0.00001
T2DM	9	1086	690	1.00 [0.79, 1.26]	0.99	81	<0.00001
PCOS	5	631	559	1.09 [0.85, 1.39]	0.49	54	0.07
MetS	3	1084	1960	0.75 [0.49, 1.14]	0.18	72	0.03
T allele	18	4992	6230	1.01 [0.89, 1.15]	0.85	73	<0.00001
T2DM	9	1086	690	1.00 [0.79, 1.26]	0.99	81	<0.00001
PCOS	5	631	559	0.92 [0.72, 1.17]	0.49	54	0.07
MetS	3	1084	1960	1.33 [0.87, 2.02]	0.19	73	0.03
Ethic
CC/CT + TT	17	4892	6130	1.01 [0.80, 1.28]	0.92	80	<0.00001
Caucasian	4	1068	585	1.36 [0.77, 2.41]	0.29	83	0.0006
Caucasian (dark)	8	1240	1019	0.75 [0.41, 1.36]	0.35	86	<0.00001
Asian	5	2584	4526	1.13 [0.98, 1.30]	0.1	24	0.26
CC + CT/TT	17	4892	6130	0.91 [0.69, 1.20]	0.49	76	<0.00001
Caucasian	4	1068	585	1.25 [0.90, 1.74]	0.19	21	0.28
Caucasian (dark)	8	1240	1019	0.54 [0.26, 1.11]	0.09	82	<0.00001
Asian	5	2584	4526	1.13 [0.87, 1.47]	0.36	56	0.06
C allele	17	4892	6130	0.99 [0.86, 1.13]	0.83	74	<0.00001
Caucasian	4	1068	585	1.24 [0.92, 1.69]	0.16	74	0.01
Caucasian (dark)	8	1240	1019	0.77 [0.57, 1.04]	0.09	74	0.0003
Asian	5	2584	4526	1.06 [0.94, 1.18]	0.35	49	0.1
T allele	17	4892	6130	1.01 [0.89, 1.16]	0.84	74	<0.00001
Caucasian	4	1068	585	0.80 [0.59, 1.09]	0.16	74	0.01
Caucasian (dark)	8	1240	1019	1.29 [0.96, 1.74]	0.09	74	0.0003
Asian	5	2584	4526	0.95 [0.85, 1.06]	0.33	46	0.12
Latitude
CC/CT + TT	18	4992	6230	1.03 [0.82, 1.30]	0.79	80	<0.00001
Low (<30)	5	852	791	1.00 [0.65, 1.52]	0.99	52	0.08
Middle (30–60)	13	4140	5439	1.03 [0.79, 1.36]	0.82	84	<0.00001
CC + CT/TT	18	4992	6230	0.92 [0.72, 1.17]	0.49	74	<0.00001
Low (<30)	5	852	791	0.78 [0.60, 1.01]	0.06	0	0.75
Middle (30–60)	13	4140	5439	0.94 [0.69, 1.26]	0.66	80	<0.00001
C allele	18	4992	6230	0.99 [0.87, 1.12]	0.84	73	<0.00001
Low (<30)	5	852	791	0.91 [0.74, 1.11]	0.36	33	0.2
Middle (30–60)	13	4140	5439	1.01 [0.86, 1.18]	0.93	78	<0.00001
T allele	18	4992	6230	1.01 [0.89, 1.15]	0.85	73	<0.00001
Low (<30)	5	852	791	1.10 [0.90, 1.35]	0.36	33	0.2
Middle (30–60)	13	4140	5439	0.99 [0.85, 1.16]	0.92	78	<0.00001

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