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Table 2 Effects of the SL extract on body lipid accumulation and serum components in mice

From: Sake lees extract improves hepatic lipid accumulation in high fat diet-fed mice

 

ND group

HFD group

SL extract group

Final body weight, g

25.5 ± 1.0b

33.4 ± 1.0

33.5 ± 1.8

4 week total food intake, g/mouse

85.8

119.6

125.3

8 week total food intake, g/mouse

159.5

204.7

216.6

Liver, g/100 g body weight

3.56 ± 0.12

3.69 ± 0.09

3.16 ± 0.19a

Epididymal WAT, g/100 g body weight

3.01 ± 0.15c

6.78 ± 0.56

6.22 ± 0.43

Serum glucose, mg/dL

43.0 ± 4.2c

173.0 ± 10.9

140.8 ± 2.6a

Serum Insulin, ng/mL

0.29 ± 0.07b

0.93 ± 0.14

0.46 ± 0.07a

HOMA-IR

0.33 ± 0.09b

2.14 ± 0.35

0.85 ± 0.13b

Serum glycoalbumin, %

3.7 ± 0.1c

4.5 ± 0.1

4.1 ± 0.1b

Serum T-CHO, mg/dL

77.0 ± 5.5c

169.8 ± 6.3

141.0 ± 4.7b

Serum TG, mg/dL

69.5 ± 8.7a

45.1 ± 7.6

39.8 ± 2.9

Serum FFA, mEq/L

1.03 ± 0.02b

0.82 ± 0.06

0.79 ± 0.03

Serum ketone bodies, mmol/L

2.03 ± 0.01

2.40 ± 0.14

3.18 ± 0.23b

Serum ALT, IU/L

17.5 ± 1.2c

87.1 ± 10.8

31.9 ± 5.9c

Serum AST, IU/L

49.5 ± 1.7c

146.6 ± 13.9

79.0 ± 8.3c

  1. Data are expressed as the mean ± SEM of five mice (ND group), nine mice (HFD group and nine mice (SL extract group) except total food intake. Statistically significant differences between groups were determined using ANOVA; a p < 0.05,b p < 0.01,c p < 0.001 vs. the HFD group