Controls | HeFH | HoFH | P | |
---|---|---|---|---|
Total-C (mmol/L) | 5.21 ± 0.92 | 8.55 ± 1.64* | 10.54 ± 2.41*,** | <0.0001 |
LDL-C (mmol/L) | 3.22 ± 0.85 | 6.89 ± 1.51* | 8.88 ± 2.58*,** | <0.0001 |
HDL-C (mmol/L) | 1.30 ± 0.31 | 1.03 ± 0.26* | 1.02 ± 0.34* | <0.0001 |
Plasma triglycerides (mmol/L) | 1.53 ± 0.71 | 1.52 ± 0.79 | 1.42 ± 0.56 | 0.9 |
Plasma apoB (mg/dL) | 118.8 ± 50.9 | 207.1 ± 138.3* | 601.3 ± 203.7*,** | <0.0001 |
Plasma apoB-48 (μg/mL) | 3.03 ± 2.07 | 6.55 ± 4.24* | 14.71 ± 4.36*,** | <0.0001 |
Plasma PCSK9 (ng/mL) | 194.5 ± 65.9 | 324.9 ± 119.8* | 642.6 ± 246.9*,** | <0.0001 |