Skip to main content

Table 3 Changes in biochemical parameters after 16 weeks of intervention

From: Effect of oral cinnamon intervention on metabolic profile and body composition of Asian Indians with metabolic syndrome: a randomized double -blind control trial

Biochemical parameters Cinnamon group (n = 58) Placebo group (n = 58) Difference between Means (95% CI) P value a
Intention to treat analysis
FBG (mmol/L)
Baseline 5.7 ± 0.6 5.6 ± 0.5 −0.1(− 0.2, 0.1) 0.485
16 weeks
 Unadjusted 5.2 ± 0.3 5.5 ± 0.4 0.3 (0.1, 0.4) 0.001*
 Adjusted 0.3 (0.2, 0.5) b 0.001*
Per protocol analysis
FBG (mmol/L)
  (n = 52) (n = 51)  
Baseline 5.7 ± 0.6 5.6 ± 0.5 −0.1 (− 0.3, 0.1) 0.528
16 weeks
 Unadjusted 5.2 ± 0.3 5.5 ± 0.4 0.3 (0.1, 0.4) 0.001*
 Adjusted 0.4 (0.2, 0.5) b 0.001*
Intention to treat analysis
HbA1c (mmol/mol)
Baseline 43.7 ± 5.4 42.4 ± 6.07 −1.3 (−3.3, 0.8) 0.250
16 weeks
 Unadjusted 39.6 ± 5.01 42.5 ± 6.8 2.9 (0.6, 5.08) 0.011*
 Adjusted 2.6 (0.4, 4.9) b 0.023*
PPG (mmol/L)
Baseline 7.4 ± 1.6 7.3 ± 1.4 −0.1 (−0.6, 0.4) 0.727
16 weeks
 Unadjusted 6.9 ± 1.4 7.4 ± 1.4 0.5 (−0.01, 1.06) 0.055*
 Adjusted 0.6 (0.1, 1.2) b 0.030*
Total cholesterol (mmol/L)
Baseline 5.23 ± 0.71 5.05 ± 0.94 −0.17 (− 0.48, 0.13) 0.259
16 weeks
 Unadjusted 4.68 ± 0.64 5.09 ± 0.92 0.41 (0.10, 0.69) 0.007*
 Adjusted 0.42 (0.12, 0.73) b 0.006*
Serum Triglycerides (mmol/L)
Baseline 1.97 ± 0.44 1.91 ± 0.48 −0.06 (−0.23, 0.10) 0.468
16 weeks
 Unadjusted 1.65 ± 0.39 1.93 ± 0.47 0.28 (0.11, 0.43) 0.001*
 Adjusted 0.20 (0.05, 0.35) b 0.010*
HDL (mmol/L)
Baseline 0.97 ± 0.15 0.96 ± 0.23 −0.003 (−0.07, 0.06) 0.922
16 weeks
 Unadjusted 1.02 ± 0.15 0.94 ± 0.22 0.08 (0.01, 0.15) 0.024*
 Adjusted 0.08 (0.005, 0.15) b 0.035*
LDL (mmol/L)
Baseline 3.46 ± 0.60 3.29 ± 0.68 - 0.16 (−0.40, 0.07) 0.178
16 weeks
 Unadjusted 3.01 ± 0.58 3.33 ± 0.66 0.32 (0.09, 0.55) 0.006*
 Adjusted 0.37 (0.13, 0.60) b 0.003*
LDL: HDL
Baseline 3.62 ± 0.79 3.55 ± 0.98 - 0.07 (−0.40, 0.25) 0.641
16 weeks
 Unadjusted 2.97 ± 0.68 3.66 ± 0.98 0.69 (0.37,0.99) 0.001*
 Adjusted 0.72 (0.40, 1.04) b 0.001*
hs- CRPc
Baseline 2.8 (2.33–3.30) 2.4 (1.98–2.86) - 0.255
16 weeks 2.5 (2.03–2.94) 2.6 (2.21–3.09) - 0.382
  1. CI confidence interval, FBG fasting blood glucose, HbA1c glycosylated haemoglobin, HDL-C high-density lipoprotein cholesterol, LDL–C low-density lipoprotein cholesterol, LDL: HDL low-density lipoprotein cholesterol high-density lipoprotein cholesterol ratio, PPG postprandial blood sugar
  2. a Intervention versus placebo
  3. b Difference between placebo and cinnamon groups adjusted for BMI using analysis of covariance
  4. cValues depicted as geometric mean (95%CI)
  5. *p value <0.05