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Table 1 Characteristics of studies related to the associations of rs50515 and rs11591147 with lipids levels

From: What is the impact of PCSK9 rs505151 and rs11591147 polymorphisms on serum lipids level and cardiovascular risk: a meta-analysis

Author Year Ethnicity Type of study Sample size SNP Genotyping method Age(year) Sex(M/F) MAF (%) HWE
He, X M [27] 2016 Asians C-C 233 rs505151 PCR-RFLP 63.95 ± 12.35 130/103 13.9 0.015
Jeenduang, N1 [28] 2015 Asians Cohort 307 rs505151 PCR-RFLP NA 97/210 1.95 0.727
Jeenduang, N2 [28] 2015 Asians Cohort 188 rs505151 PCR-RFLP NA 38/150 1.06 0.883
Yuqian, Mo [29] 2015 Asians C-C 100 rs505151 TaqMan 56.4 ± 11.7 58/42 7.19 0.000
Anderson, J M1 [30] 2014 Caucasians C-C 171 rs505151 PCR-RFLP 47 ± 7 108/55 12.6 NA
Anderson, J M2 [30] 2014 Caucasians C-C 163 rs505151 PCR-RFLP 55 ± 10 127/44 14.7 NA
Slimani, A [31] 2014 Caucasians C-C 258 rs505151 PCR-RFLP Case:55 (52–65) Control:61 (55–67) 212/46 0.88 0.000
Mayne, J [32] 2013 Caucasians Cohort 207 rs505151 PCR-RFLP NA NA 0.036 0.591
Aung, L H1 [33] 2013 Asians Cohort 567 rs505151 PCR-RFLP 45.13 ± 13.35 456/111 0.021 0.60
Aung, L H2 [33] 2013 Asians Cohort 785 rs505151 PCR-RFLP 47.36 ± 14.34 573/212 0.026 0.453
Meng yanhui [34] 2011 Asians Cohort 165 rs505151 PCR-RFLP 66.49 ± 9.92 102/63 0.058 0.430
Zeng jian [35] 2011 Asians C-C 212 rs505151 PCR-RFLP NA NA 0.123 0.020
Norata, G D [36] 2010 Caucasians Cohort 1541 rs505151 Taqman 54.71 ± 10.97 621/923 0.024 0.32
Hsu, L A1 [37] 2009 Asians C-C 202 rs505151 PCR-RFLP 55.6 ± 10.5 171/31 0.046 0.513
Hsu, L A2 [37] 2009 Asians C-C 614 rs505151 PCR-RFLP 45.9 ± 10.4 325/289 0.060 0.381
Polisecki, E [38] 2008 Caucasians Cohort 5416 rs505151 Taqman 75.64 ± 3.38 2620/2795 0.030 0.072
Scartezini, M [39] 2007 Caucasians Cohort 2444 rs505151 PCR-RFLP 50–61 2444(M) 0.065 0.788
Evans, D [40] 2006 Caucasians Cohort 506 rs505151 PCR-RFLP 44 ± 14 239/267 0.050 0.111
Chen, SN [41] 2005 Caucasians Cohort 372 rs505151 PCR-RFLP 58.8 ± 7.7 310/62 0.074 0.000
Jeenduang, N1 [28] 2015 Asians Cohort 97 rs11591147 PCR-RFLP NA 97(M) 0.031 0.753
Jeenduang, N2 [28] 2015 Asians Cohort 209 rs11591147 PCR-RFLP NA NA 0.019 0.778
Bonnefond, A [42] 2015 Caucasians C-C 4319 rs11591147 Metabochip 46.7 ± 10.0 2272/2246 0.020 0.179
Saavedra, YG [43] 2014 Caucasians Cohort 560 rs11591147 PCR-RFLP 37.0 ± 13.9 329/231 0.016 0.699
Guella, I [44] 2010 Caucasians c-c 3453 rs11591147 Taqman 39.6 ± 4.9 3039/414 NA NA
Strom, T B [45] 2010 Caucasians Cohort 1130 rs11591147 PCR-RFLP 34 ± 13.3 536/594 NA NA
Huang, C C [46] 2009 Caucasians Cohort 1828 rs11591147 Taqman 25.5 ± 3.4 852/916 NA NA
Humphries, S E [47] 2009 Caucasians Cohort 81 rs11591147 PCR-RFLP 56 ± 3.6 81(M) 0.253 0.840
Polisecki, E [38] 2008 Caucasians Cohort 5413 rs11591147 Taqman 75.64 ± 3.38 2619/2794 0.018 0.069
  1. Abbreviations: C-C case-control, M male, F female, MAF minor allelic frequencies, HWE Hardy-Weinberg equilibrium, NA not assess