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Table 2 Characteristics of the studies related to the associations of rs50515 and rs11591147 with cardiovascular risk

From: What is the impact of PCSK9 rs505151 and rs11591147 polymorphisms on serum lipids level and cardiovascular risk: a meta-analysis

Author Year Ethnicity Subgroup Type of study Sample size SNP Genotyping method Age(year) Sex (M/F) MAF (%) HWE (p)
He, X M [27] 2016 Asians CHD C-C 472 rs505151 PCR-RFLP 62.80 ± 12.76 251/221 0.056 0.07
Yuqian, Mo [29] 2015 Asians CHD C-C 200 rs505151 Taqman 55.55 ± 10.98 114/86 0.040 0.677
Yangchun [48] 2015 Asians MI C-C 342 rs505151 PCR-RELP 58.38 ± 6.45 200/144 0.038 0.589
Slimani, A1 [31] 2014 Asians CHD C-C 258 rs505151 PCR-RFLP Case:55 (52–65) Control:61 (55–67) 212/46 0.068 0.552
Slimani, A3 [31] 2014 Caucasians IS C-C 346 rs505151 PCR-RELP Case:66 (54.5–76.5) Control:49 (45–55) 237/109 0.073 0.812
Lei, Jing [49] 2014 Caucasians IS C-C 756 rs505151 SNaPshot 61.91 ± 112 425/331 0.056 0.925
Meng yanhui [34] 2011 Asians CHD C-C 345 rs505151 PCR-RFLP 65.37 ± 13.06 200/180 0.039 0.587
Zeng jian [35] 2011 Asians CHD C-C 396 rs505151 PCR-RFLP NA NA 0.057 0.055
Guella, I [44] 2010 Caucasians MI C-C 4643 rs505151 PCR-RELP 36.69 ± 4.92 3317/420 NA NA
Hsu, L A [37] 2009 Asians CHD C-C 816 rs505151 PCR-RFLP 48.30 ± 11.23 496/320 0.060 0.381
Scartezini, M [39] 2007 Caucasians CHD C-C 2065 rs505151 PCR-RFLP 56.16 ± 3.41 2065(M) 0.033 0.465
Abboud, S [50] 2007 Caucasians IS C-C 564 rs505151 TaqMan Case(53.5) Control(70.3) NA 0.075 0.012
Saavedra, Y G3 [43] 2014 Caucasians Cohort Cohort 560 rs11591147 PCR-RFLP 37.0 ± 13.9 329/231 0.016 0.699
Benn, M1 [21] 2010 Caucasians C-C C-C 10,032 rs11591147 Taqman 58.0 (44–690 4514/5518 0.012 0.676
Benn, M2 [21] 2010 Caucasians C-C C-C 26,013 rs11591147 Taqman 59.8 (51–69) 12746/13267 0.014 0.334
Benn, M3 [21] 2010 Caucasians C-C C-C 9654 rs11591147 Taqman 60.0 (51–69) 5599/4055 0.012(total) 0.748
Guella, I [44] 2010 Caucasians C-C C-C 4733 rs11591147 Taqman 39.6 ± 4.9 3039/414 NA NA
Huang, C C [46] 2009 Caucasians Cohort Cohort 1828 rs11591147 Taqman 25.52 ± 3.41 882/946 0.170 0.505
Polisecki, E1 [38] 2008 Caucasians Cohort Cohort 5413 rs11591147 Taqman 75.64 ± 3.38 2619/2794 0.018 0.840
Scartezini, M [39] 2007 Caucasians C-C C-C 2444 rs11591147 PCR 50–61 2444(M) 0.010 0.074
  1. Abbreviations: CHD coronary heart disease, MI myocardial infarction, IS ischemic stroke, C-C case-control, M male, F female, MAF minor allelic frequencies, HWE Hardy-Weinberg equilibrium, NA not assess