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Table 3 Associations of rs505151 and rs11591147 variants with serum lipids levels and blood pressure

From: What is the impact of PCSK9 rs505151 and rs11591147 polymorphisms on serum lipids level and cardiovascular risk: a meta-analysis

SNP variant allele Lipid traits or BP Sub- group No. of Study Sample size effect model SMD 95% CI P I2% Phet Begg ‘(P) Egger’s (P) Venice criteria Level of evidence
rs505151 G TC Asians 11 3318 random 0.16 (−0.06,0.38) 0.151 62.9 0.003 0.815 0.407 BCA weak
rs505151 G TC Caucasians 9 9664 random 0.03 (−0.14,0.21) 0.716 76.0 0.000 0.532 0.151 BCA weak
rs505151 G TC Overall 20 12,982 random 0.09 (−0.04,0.22) 0.190 68.5 0.000 0.846 0.601 ACA weak
rs505151 G TG Asians 12 3373 fixed 0.14 (0.02,0.26) 0.021 0.0 0.529 0.586 0.411 BAA Moderate
rs505151 G TG Caucasians 7 3183 fixed −0.09 (−0.21,0.03) 0.127 23.9 0.247 0.099 0.294 BAA Moderate
rs505151 G TG Overall 19 6556 fixed 0.02 (−0.06,0.11) 0.596 30.0 0.112 0.472 0.623 BBA Moderate
rs505151 G LDL-C Asians 11 3335 random 0.28 (−0.07,0.62) 0.113 84.2 0.000 0.312 0.190 BCA weak
rs505151 G LDL-C Caucasians 8 4248 random 0.11 (−0.02,0.24) 0.111 37.6 0.129 0.805 0.710 BBA Moderate
rs505151 G LDL-C Overall 19 7583 random 0.17 (0.00,0.35) 0.046 75.9 0.000 0.151 0.092 BCA weak
rs505151 G HDL-C Asians 11 3273 fixed −0.16 (−0.19,0.06) 0.340 44.1 0.065 0.245 0.560 BBA Moderate
rs505151 G HDL-C Caucasians 8 4248 fixed 0.02 (−0.08,0.12) 0.673 0.0 0.803 0.095 0.091 BAA Moderate
rs505151 G HDL-C Overall 19 7521 fixed −0.01 (−0.09,0.07) 0.792 18.7 0.230 0.103 0.154 BAA Moderate
rs505151 G DBP Mixed 8 5079 fixed −0.08 (−0.21,0.05) 0.224 0.0 0.692 0.805 0.810 BAA Moderate
rs505151 G SBP Mixed 8 5079 fixed −0.06 (−0.19,0.06) 0.332 7.0 0.376 0.805 0.643 BAA Moderate
rs11591147 T TC Asians 2 306 random −0.50 (−1.44,0.44) 0.299 66.5 0.084    CCA weak
rs11591147 T TC Caucasians 6 9496 random −0.45 (−0.57,-0.32) 0.000 0.0 0.936 0.851 0.913 BAA Moderate
rs11591147 T TC Overall 8 9802 random −0.45 (−0.57,-0.33) 0.000 0.0 0.733 1.000 0.869 BAA Moderate
rs11591147 T TG Asians 2 306 fixed −0.43 (−0.97,0.11) 0.119 0.0 0.447    CAA weak
rs11591147 T TG Caucasians 5 9254 fixed 0.00 (−0.11,0.11) 0.996 0.0 0.685 0.624 0.436 BAA Moderate
rs11591147 T TG Overall 7 9560 fixed −0.02 (−0.13,0.09) 0.747 0.0 0.522 0.176 0.102 BAA Moderate
rs11591147 T LDL-C Asians 2 306 fixed −0.53 (−1.07,0.01) 0.053 0.0 0.436     
rs11591147 T LDL-C Caucasians 5 10,299 fixed −0.44 (−0.55,-0.33) 0.000 0.0 0.548 0.142 0.125 BAA Moderate
rs11591147 T LDL-C Overall 7 10,605 fixed −0.44 (−0.55,-0.33) 0.000 0.00.0 0.707 0.293 0.206 BAA Moderate
rs11591147 T HDL-C Mixed 7 9560 fixed 0.10 (−0.01,0.21) 0.074 35.4 0.158 0.453 0.026 BBB Moderate
rs11591147 T DBP Mixed 5 2797 random 3.60 (−0.71,7.9) 0.101 77.4 0.001 0.624 0.318 CCA weak
rs11591147 T SBP Mixed 5 2797 random 1.79 (−2.78,6.37) 0.442 45.6 0.118 0.624 0.306 CBA weak
  1. Abbreviations: SMD standardized mean difference, 95%C 95% confidence interval, TC cholesterol, TG triglyceride, LDL-C low-density lipoprotein cholesterol, HDL-C high density lipoprotein cholesterol, SBP systolic blood pressure, DBP diastolic blood pressure