What is the impact of PCSK9 rs505151 and rs11591147 polymorphisms on serum lipids level and cardiovascular risk: a meta-analysis

Qiu, Chengfeng; Zeng, Pingyu; Li, Xiaohui; Zhang, Zhen; Pan, Bingjie; Peng, Zhou Y. F.; Li, Yapei; Ma, Yeshuo; Leng, Yiping; Chen, Ruifang

doi:10.1186/s12944-017-0506-6

Lipids in Health and Disease

Table 3 Associations of rs505151 and rs11591147 variants with serum lipids levels and blood pressure

From: What is the impact of PCSK9 rs505151 and rs11591147 polymorphisms on serum lipids level and cardiovascular risk: a meta-analysis

SNP	variant allele	Lipid traits or BP	Sub- group	No. of Study	Sample size	effect model	SMD	95% CI	P	I2%	Phet	Begg ‘(P)	Egger’s (P)	Venice criteria	Level of evidence
rs505151	G	TC	Asians	11	3318	random	0.16	(−0.06,0.38)	0.151	62.9	0.003	0.815	0.407	BCA	weak
rs505151	G	TC	Caucasians	9	9664	random	0.03	(−0.14,0.21)	0.716	76.0	0.000	0.532	0.151	BCA	weak
rs505151	G	TC	Overall	20	12,982	random	0.09	(−0.04,0.22)	0.190	68.5	0.000	0.846	0.601	ACA	weak
rs505151	G	TG	Asians	12	3373	fixed	0.14	(0.02,0.26)	0.021	0.0	0.529	0.586	0.411	BAA	Moderate
rs505151	G	TG	Caucasians	7	3183	fixed	−0.09	(−0.21,0.03)	0.127	23.9	0.247	0.099	0.294	BAA	Moderate
rs505151	G	TG	Overall	19	6556	fixed	0.02	(−0.06,0.11)	0.596	30.0	0.112	0.472	0.623	BBA	Moderate
rs505151	G	LDL-C	Asians	11	3335	random	0.28	(−0.07,0.62)	0.113	84.2	0.000	0.312	0.190	BCA	weak
rs505151	G	LDL-C	Caucasians	8	4248	random	0.11	(−0.02,0.24)	0.111	37.6	0.129	0.805	0.710	BBA	Moderate
rs505151	G	LDL-C	Overall	19	7583	random	0.17	(0.00,0.35)	0.046	75.9	0.000	0.151	0.092	BCA	weak
rs505151	G	HDL-C	Asians	11	3273	fixed	−0.16	(−0.19,0.06)	0.340	44.1	0.065	0.245	0.560	BBA	Moderate
rs505151	G	HDL-C	Caucasians	8	4248	fixed	0.02	(−0.08,0.12)	0.673	0.0	0.803	0.095	0.091	BAA	Moderate
rs505151	G	HDL-C	Overall	19	7521	fixed	−0.01	(−0.09,0.07)	0.792	18.7	0.230	0.103	0.154	BAA	Moderate
rs505151	G	DBP	Mixed	8	5079	fixed	−0.08	(−0.21,0.05)	0.224	0.0	0.692	0.805	0.810	BAA	Moderate
rs505151	G	SBP	Mixed	8	5079	fixed	−0.06	(−0.19,0.06)	0.332	7.0	0.376	0.805	0.643	BAA	Moderate
rs11591147	T	TC	Asians	2	306	random	−0.50	(−1.44,0.44)	0.299	66.5	0.084			CCA	weak
rs11591147	T	TC	Caucasians	6	9496	random	−0.45	(−0.57,-0.32)	0.000	0.0	0.936	0.851	0.913	BAA	Moderate
rs11591147	T	TC	Overall	8	9802	random	−0.45	(−0.57,-0.33)	0.000	0.0	0.733	1.000	0.869	BAA	Moderate
rs11591147	T	TG	Asians	2	306	fixed	−0.43	(−0.97,0.11)	0.119	0.0	0.447			CAA	weak
rs11591147	T	TG	Caucasians	5	9254	fixed	0.00	(−0.11,0.11)	0.996	0.0	0.685	0.624	0.436	BAA	Moderate
rs11591147	T	TG	Overall	7	9560	fixed	−0.02	(−0.13,0.09)	0.747	0.0	0.522	0.176	0.102	BAA	Moderate
rs11591147	T	LDL-C	Asians	2	306	fixed	−0.53	(−1.07,0.01)	0.053	0.0	0.436
rs11591147	T	LDL-C	Caucasians	5	10,299	fixed	−0.44	(−0.55,-0.33)	0.000	0.0	0.548	0.142	0.125	BAA	Moderate
rs11591147	T	LDL-C	Overall	7	10,605	fixed	−0.44	(−0.55,-0.33)	0.000	0.00.0	0.707	0.293	0.206	BAA	Moderate
rs11591147	T	HDL-C	Mixed	7	9560	fixed	0.10	(−0.01,0.21)	0.074	35.4	0.158	0.453	0.026	BBB	Moderate
rs11591147	T	DBP	Mixed	5	2797	random	3.60	(−0.71,7.9)	0.101	77.4	0.001	0.624	0.318	CCA	weak
rs11591147	T	SBP	Mixed	5	2797	random	1.79	(−2.78,6.37)	0.442	45.6	0.118	0.624	0.306	CBA	weak

Abbreviations: SMD standardized mean difference, 95%C 95% confidence interval, TC cholesterol, TG triglyceride, LDL-C low-density lipoprotein cholesterol, HDL-C high density lipoprotein cholesterol, SBP systolic blood pressure, DBP diastolic blood pressure

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