What is the impact of PCSK9 rs505151 and rs11591147 polymorphisms on serum lipids level and cardiovascular risk: a meta-analysis

Table 4 Associations of rs505151 and rs11591147 variants with cardiovascular risk

SNP	Variant allele	Subgroup	No. of Study	Sample size	effect model	OR	95% CI	P value	I²%	P_het	Begg’ (P)	Egger’s (P)	Venice criteria	Level of evidence
rs505151	G	Asians	8	1672	random	1.59	(1.12,2.27)	0.009	60	0.01	0.805	0.437	BCA	Weak
rs505151	G	Caucasians	4	2369	random	1.31	(1.04,1.65)	0.02	0	0.45	0.042	0.229	BAA	Moderate
rs505151	G	Overall		4041	random	1.50	(1.19,1.89)	0.0006	48	0.03	0.493	0.144	BBA	Moderate
rs11591147	T	Caucasians	9	66,090	random	0.77	(0.60,0.98)	0.031	59.9	0.015	0.216	0.165	BCA	Weak

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