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Table 4 Associations of rs505151 and rs11591147 variants with cardiovascular risk

From: What is the impact of PCSK9 rs505151 and rs11591147 polymorphisms on serum lipids level and cardiovascular risk: a meta-analysis

SNP Variant allele Subgroup No. of Study Sample size effect model OR 95% CI P value I2% Phet Begg’ (P) Egger’s (P) Venice criteria Level of evidence
rs505151 G Asians 8 1672 random 1.59 (1.12,2.27) 0.009 60 0.01 0.805 0.437 BCA Weak
rs505151 G Caucasians 4 2369 random 1.31 (1.04,1.65) 0.02 0 0.45 0.042 0.229 BAA Moderate
rs505151 G Overall   4041 random 1.50 (1.19,1.89) 0.0006 48 0.03 0.493 0.144 BBA Moderate
rs11591147 T Caucasians 9 66,090 random 0.77 (0.60,0.98) 0.031 59.9 0.015 0.216 0.165 BCA Weak
  1. Abbreviations: OR odds ratio, 95% CI 95% confidence interval