Quantitative trait loci at the 11q23.3 chromosomal region related to dyslipidemia in the population of Andhra Pradesh, India

Pranavchand, Rayabarapu; Reddy, Battini Mohan

doi:10.1186/s12944-017-0507-5

Lipids in Health and Disease

Table 1 Significant allelic associations of SNPs at 11q23.3 chromosomal region with the quantitative lipid traits obtained through linear regression analysis^a

From: Quantitative trait loci at the 11q23.3 chromosomal region related to dyslipidemia in the population of Andhra Pradesh, India

SNP	Total cholesterol		LDL cholesterol		Triglycerides		VLDL
SNP	β (95% CI)	p value	β (95% CI)	p value	β (95% CI)	p value	β (95% CI)	p value
rs11216126					−0.08 (−0.18 - -0.002)	0.056*
rs11216129					−0.08 (−0.18 - -0.002)	0.055*
rs17440396	0.10 (0.01–0.19)	0.022
rs10488699			0.09 (0.002–0.18)	0.044
rs17119975					−0.09 (−0.18 - -0.003)	0.043	−0.09 (−0.18 - -0.003)	0.043
rs2187126	0.18 (0.09–0.27)	6.29 × 10 ⁻⁵	0.18 (0.09–0.27)	5.55 × 10 ⁻⁵
rs1942478					−0.11 (−0.20 - -0.02)	0.017	−0.11 (−0.20 - -0.19)	0.017
rs4417316					−0.10 (−0.19 - -0.01)	0.025	−0.10 (−0.19 - -0.01)	0.029
rs6589566	−0.10 (−0.23 - -0.05)	0.0018	−0.15 (−0.25 - -0.06)	0.0007
rs633389	0.18 (0.08–0.27)	0.0001	0.21 (0.12–0.30)	4.75 × 10 ⁻⁶
rs633867			0.09 (0.002–0.18)	0.044
rs672143	−0.01 (−0.18 - -0.008)	0.033			−0.09 (−0.18 - -0.003)	0.042
rs6589567					0.08 (−0.005–0.17)	0.067*	0.08 (−0.005–0.17)	0.067*
rs1263163	0.30 (0.21–0.38)	6.24 × 10 ⁻¹¹	0.28 (0.20–0.37)	2.73 × 10 ⁻¹⁰
rs2849165			0.09 (0.002–0.1 8)	0.045
rs2854117					0.10 (0.01–0.19)	0.024	0.10 (0.01–0.19)	0.026
rs2854116	−0.10 (−0.20–0.003)	0.044			−0.11 (−0.21 - -0.01)	0.021	−0.11 (−0.21 - -0.01)	0.024
rs5132	0.09 (−0.0001–0.018)	0.051*	0.10 (0.01–0.19)	0.027
rs11216153	−0.009 (−0.18 - -0.005)	0.038
rs5081	0.13 (0.04–0.22)	0.003	0.13 (0.04–0.22)	0.0034	0.09 (0.003–0.18)	0.042	0.09 (0.002–0.18)	0.043
rs5072					0.09 (0.0002–0.18)	0.049
rs632153	0.13 (0.03–0.22)	0.006	0.11 (0.02–0.20)	0.0139	0.11 (0.02–0.20)	0.014	0.11 (0.02–0.20)	0.015

β-Standardized linear regression coefficient, Blank cell – Non significant, bold font indicates significant after Benjamin Hochberg correction
*Significant after adjusting for covariates
^aResults for lone SNP (rs918144(C) that belong to BUD13 gene) associated with HDLC are not given in the table but described with text

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