Table 2 Significant haplotypes at 11q23.3 chromosomal region associated with LDL Cholesterol and Total cholesterol obtained through linear regression analysis
SNPs in Haplotype block | Haplotype | Frequency | LDL Cholesterol | Total cholesterol | ||
|---|---|---|---|---|---|---|
β (95% CI) | p value | β (95% CI) | p value | |||
rs623908, rs664059 | AC | 0.21 | −6.06 (−11.1, −1.0) | 0.018 | ||
rs6589566, rs2075290 | GC | 0.20 | −5.22 (−10.4, −0.1) | 0.047* | ||
GT | 0.05 | −18.4 (−28.2, −8.6) | 0.0002 | −28.3 (−39.3, −17.3) | 7.39 × 10−07 | |
AT | 0.74 | 7.97 (3.5, 12.4) | 0.0005 | 8.44 (3.3, 13.5) | 0.0012 | |
rs633389, rs633867 | TT | 0.05 | 9.68 (0.5, 18.8) | 0.038 | ||
TC | 0.10 | 16.5 (9.1, 23.9) | 1.47 × 10−05 | 16.4 (7.9, 24.9) | 0.0001 | |
CC | 0.84 | −13.1 (−18.7, −7.5) | 5.25 × 10−06 | −12.6 (−19.0, −6.2) | 0.0001 | |
rs5132, rs5128, rs11216153 | TGG | 0.039 | 17.7 (6.2, 29.2) | 0.0027 | 19.1 (5.9, 32.3) | 0.0047 |