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Fig. 6 | Lipids in Health and Disease

Fig. 6

From: Hyperlipidemic microenvironment conditionates damage mechanisms in human chondrocytes by oxidative stress

Fig. 6

Graphic representation of the role of obesity: On oxidative stress leading to cytokine and chemokine autocrine production in OA. In this figure, it is possible to appreciate that the relation between obesity and OA is more than biomechanical stress where an increase in lipid composition in the cartilage induces the formation of pro-inflammatory mediators, ROS and RNS leading to cartilage damage

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Lipids in Health and Disease

ISSN: 1476-511X